Polycystic Ovary Syndrome and Cardiometabolic Risk

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Insulin resistance and endocrine abnormalities are believed to play a role in the pathogenesis of PCOS. Metabolic syndrome is twice as common in patients with PCOS compared with the general population. Patients with PCOS are more likely to develop type 2 diabetes mellitus and hypertension which are risk factors for heart disease and stroke. Guidelines recommend using the Rotterdam criteria for diagnosis, which requires the presence of two of the following three findings: hyperandrogenism, ovulatory dysfunction, and polycystic ovaries on ultrasound scan and the exclusion of other diagnoses that could result in hyperandrogenism or ovulatory dysfunction.

The aim of this exciting project is to further explore the association of metabolic and endocrinological risk factors in PCOS and long-term health outcomes and will involve research in clinical settings as well as data science.

As a PhD student in one of the science departments at Imperial College, you will get access to training opportunities designed to help you gain essential skills and support your career development. The successful applicant will join an internationally renowned research team, within one of the world’s top research universities.

You will be exposed to state-of-the-art facilities and you will benefit from an integrated training programme including training in reproductive endocrinology, clinical imaging, experimental approaches in translational medicine, laboratory techniques and statistical methodology. You will complete a series of courses from the award-winning Imperial College Graduate School. You will be encouraged to attend journal clubs and receive training in how to critically appraise scientific literature, presentation and writing skills. The department has an excellent publication record in top rated research journals. The student will be encouraged to publish and present their work at scientific conferences.

Applicants must have a first or upper second-class degree in a relevant area of biochemistry, biology or physiology. A Master’s degree is desirable but not essential. Candidates should have the ability to work independently or as part of a team and should have good organisational and communication skills. A highly motivated and enthusiastic student with an interest in reproductive endocrinology would be ideal for this project.

This is a self-funded project; applicants will be expected to pay their own fees or have access to suitable third-party funding.