About the Project
We will work in collaboration with microbiologists at the University of Sheffield, who will test the polymers in established microbiological assays. The key polymers are highly branched poly(N-isopropyl acrylamide)s with bacteria binding ligands at the chain ends. The ligand in this case is a peptide, VPHNPGLISLQG, which has been identified by phage display techniques to selectively bind to Staphylococcus aureus.
The project will mainly involve the synthesis of these polymers and their characterisation in terms of molecular structure and physical properties with their microbiological properties being assessed at University of Sheffield. We will also examine the toxicity of the polymers in cell culture assays at Bradford.
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