Replacing a part or a function of the body in a safe, reliable, long-lasting and economic manner is the main motivation of this study. A physiologically acceptable implant requires of its multifunctionality; not only being conducive to regeneration of bone-remodelling cells but it also needs to possess the 3D structure to allow osteoinduction. Titanium and titanium alloys are non-resorbable materials that have proven to be successful as bone replacement or/and bone regeneration matrices. Their non-toxic, bioinert properties as well as their manufacturability to prevent osteopenia derived from a mismatch in mechanical properties make them good contenders in the biomaterials catalogue. Porosity tailoring at a multiscale (i.e. macro, micro and nano) can be exploited to enhance activity at the interface and therefore accelerate the integration into the osteo skeletal system.
This project will explore new manufacturing routes for the porosity tailored metal structures that then will be tested for their chemo-mechanical performance as well as their feasibility as bioengineering scaffolds and medical devices. We are seeking candidates with tissue engineering and biochemistry lab skills and an interest in developing bioengineering cell-based testing skills.
The researcher will join a multidisciplinary team of engineers, physicists and biologists already working on the different aspects of this research topic. The researcher will work in the Multifunctional Materials Manufacturing Lab and the Centre for Biological Engineering at Loughborough University.