About the Project
We have performed genome-wide transcriptome and proteomic studies to identify factors whose expression levels are modulated when trypanosomes are depleted of iron. The PhD project will use a combination of biochemical, cell biology and molecular genetic approaches (e.g. CRISPR-Cas9 genome editing, flow cytometry, immunofluorescence microscopy, RNA interference and overexpression) to study the function of these proteins, and investigate whether differences exist in iron-regulatory pathways between mammalian hosts and trypanosome parasites using omics approaches.
For more info visit our lab website: https://tiengwe.wixsite.com/website
There is also a potential for a China Scholarship Council fellowship with the following eligibility criteria:
Be a Chinese national
Meet the requirements of the CSC – View Website
Hold an unconditional offer to study for a PhD at Imperial College London
Potential to apply for President's Scholarship at Imperial College London
Fast B, Kremps K, Boshart M, & Steverding D (1999) Iron-dependent regulation of transferrin receptor expression in Trypanosoma brucei. Biochem. J. 342:691-696.
- Tiengwe, C., et al. (2017) Controlling transferrin receptor trafficking with GPI-valence in bloodstream stage African trypanosomes, PLoS Pathog 13, e1006366.
- Tiengwe, C., et al. (2018). ER-associated degradation and disposal of misfolded GPI-anchored proteins in Trypanosoma brucei, Molecular Biology of the Cell, 29:2359-2507
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