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Precision-cut lung slices to investigate the effect of human rhinovirus on cough and airway inflammation

Hull York Medical School

About the Project

The human Rhinovirus (RV) is the major cause of the common cold. There are no current treatments or vaccines for the virus other than over the counter preparations to alleviate symptoms. For most people, the RV will resolve without the need for medical intervention, however for some individuals complications can occur. These can include the post viral cough leading to a chronic cough and for those who already have chronic lung diseases such as asthma and Chronic Obstructive Pulmonary Disease (COPD), a RV infection is one of the leading causes of exacerbations. Added to this, the RV may lead to other respiratory infections including pneumonia in susceptible individuals.
The aim of the current research project is to further develop our Precision-Cut Lung Slice (PCLS) Lab-on-a-Chip model using human tissue to investigate the RV and its role in post-viral cough and airway inflammation. We hypothesise that RV infection will alter expression of channels and receptors which we have shown to be involved in cough and airway inflammation, causing the lung tissue to become hyper responsive to bronchoconstrictive agents. This work will develop a more realistic model to study how the RV causes cough and exacerbations in those already suffering from inflammatory airway diseases and it is hoped that this information can be used to develop novel therapies.
This is a full time PhD in Medical Sciences
For informal inquiries, please contact Dr. Laura Sadofsky ().
Location and Research Culture
Hull York Medical School’s unique partnership brings together the expertise of both the Universities of Hull and York and offers a thriving environment in which to conduct world-leading research. Strong partnerships with NHS Trusts and community health organisations offer a wide clinical base within which to study those conditions which most affect our communities – improving their health while developing research work that can be applied nationally and globally.
The School’s academic and clinical researchers at have a strong reputation for their work, 85% of which is classed as ‘world-leading’ or ‘internationally excellent’ (REF 2014). Their research is advancing improvements in healthcare – treatment, diagnosis and care – improving the health of people locally and impacting national and international health agendas.
The student will join a dynamic research team and thriving community of graduate students from the UK and overseas in the Centre for Atherothrombosis and Metabolic Disease at the University of Hull. Many students also study in our laboratories at local hospitals across the city. This gives our students unparalleled access to the facilities, academic and clinical expertise to thrive in their research.
Named Academic
Dr. Laura Sadofsky, Lecturer in Respiratory Medicine, Centre for Atherothrombosis and Metabolic Disease.

Start Date
To be arranged upon acceptance of an offer.
Qualification Required
In order to qualify for this position, you will require an undergraduate degree with at least a 2.1, or equivalent, in a relevant subject (Biochemistry, Molecular and Cellular Biology, Pharmacology, Pharmacy or related discipline). English Language IELTS 6.5 with a minimum of 6.0 in each component.
How to Apply
All applications MUST be submitted through the HYMS Postgraduate Centre via the online application system:
Please apply for a “PhD in Medical Sciences” at Hull York Medical School. Please quote HYMS with the project title when applying. In order for the Panel to get a sense of your academic background, commitment and interest, you are required to complete the application form in full and provide a research proposal/outline of academic interest. Research proposals and personal statements may be used in selecting applicants for interview. If you have any queries on how to apply, please email .
Interview Date
Applicants who are shortlisted for interview will be sent details of the date, time and venue via email. If you are not invited for interview, it means that your application has not been successful. Please note that we do not offer feedback to applicants who are not invited to the interview.

Funding Notes

Self-funded students only - if you have the correct qualifications and access to your own funding, either through a scholarship or your own finances, your application will be considered.
In addition to tuition fees and living expenses, funding must also include a £3,000 per year Research Training Support charge over three years to cover costs of experimental work.

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