University of Birmingham Featured PhD Programmes
Anglia Ruskin University Featured PhD Programmes
National University of Ireland, Galway Featured PhD Programmes
University of Portsmouth Featured PhD Programmes
University of Manchester Featured PhD Programmes

Precision Medicine for Squamous cell Carcinomas – NRF2/KEAP1 subtypes


Project Description

Squamous cell carcinomas (SCCs), which arise at a variety of anatomical sites from stratified squamous epithelium, represent the most frequent human solid malignancies and are a major cause of cancer mortality. Genomic landscaping studies have identified a ’classic subtype’ of SCC, including lung, head and neck and oesophageal SCCs, that is characterised by frequent NRF2 and KEAP1 mutations. We aim to use functional investigations of the NRF2 pathway and integrated proteogenomic analyses to further characterise this classic subtype in SCCs across multiple anatomical sites. This proposal will investigate its molecular pathogenesis and provide new precision medicine strategies for diagnosis, prevention and treatment including novel NRF2 inhibitors as part of a unified investigational approach to the biology, clinical investigation and treatment of SCCs.

Apply
To apply please send a cover letter, curriculum vitae and two references to:

Funding Notes

Please note this is a self-funded PhD project

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2019
All rights reserved.