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Predicting Alzheimer’s disease and vascular dementia using novel neuroimaging biomarkers


Project Description

Alzheimer’s disease and vascular dementia are the most common dementias. Predicting individuals at risk of progression to dementia remains an unmet clinical challenge. Reliable well-validated biomarkers are required to predict long-term outcomes, monitor disease progression and objectively identify disease subtypes.

This project will apply Quasi-Diffusion Imaging (QDI), a novel, diffusion magnetic resonance imaging methodology developed and patented at St George’s, University of London to identify healthy and pathological biomarkers of brain tissue. The successful applicant will develop new techniques for advanced image segmentation and multivariate machine learning and apply these to identify and classify dementias. Neuroimaging (including QDI measures), cognitive, clinical and genetic information from the UK Biobank will be used to predict longitudinal changes in cognitive abilities and progression to dementia.

SKILLS WE EXPECT A STUDENT TO DEVELOP/ACQUIRE WHILST PURSUING THIS PROJECT
Develop understanding of Ageing, Alzheimer’s disease and vascular dementia and how neuroimaging may influence patient care and clinical decisions.
- Develop understanding of Brain Tumours and how neuroimaging may influence patient care and clinical decisions.
- Knowledge of how neuroimaging methods can be applied to clinical data.
- Gain experience in processing and analysing large multimodal datasets that include clinical, imaging, biological and genetic data.
- Presentation of findings at clinical and academic conferences, in peer review publications and through public engagement.

HOW TO APPLY
Potential applicants are strongly encouraged to contact the supervisors to discuss project details.

The current studentship is part of the MRC London Intercollegiate Doctoral Training Partnership (MRC-LID) between The London School of Hygiene and Tropical Medicine (LSHTM) and St. George’s University of London (SGUL)

Subsequently applications can be made by following the instructions on the MRC-LID site at http://mrc-lid.lshtm.ac.uk/apply/.

Please click on the following link for more information about the MRC-LID programme: http://mrc-lid.lshtm.ac.uk/

For more information on funding please go to: http://mrc-lid.lshtm.ac.uk/faqs/

The deadline for applications is Wednesday 1 January 2020.

Funding Notes

To be eligible for a full studentship award applicants must
(a) hold, or expect to obtain before September 2020, a 1st or 2.1 Honours degree (as a minimum), and
(b) be a UK or EU citizen, and
(c) have maintained ordinary residence in the UK continuously for the 3 years preceding 1 September 2020.

To be generally eligible for a fees-only studentship award applicants must
(a) hold, or expect to obtain before September 2020, a 1st or 2.1 Honours degree (as a minimum), and
(b) be a UK or EU citizen.

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