About the Project
The project will employ finite element analysis to simulate the mechanical behaviour and the risk of fracture in the first phase; femurs with varying geometries and bone quality, lesion size, shape and location subjected to loadings expected from physiological activities will be analysed using the finite element method. While finite element models can be successfully applied for diagnosis of individual patients, the computational cost of modelling is high, which limits their clinical adoption. The project will, therefore, in the second phase develop a novel machine-learning based emulator which can be trained by the above database of finite element analyses. Considerable data of patients with metastatic bone disease is being collated at the University of Edinburgh as part of another project. This data will be available for finite element analysis and validation of the developed machine learning algorithms.
The candidate should have an undergraduate or a master’s degree in Engineering or Physics. They should have had undertaken courses in solid mechanics and finite element modelling. Prior experience in machine learning is not required but the candidate should be skilled in advanced programming languages such as Python, Matlab, R, C/C++ or Java and interested in machine learning and its application in biomedical engineering.
The selected candidate will be jointly supervised by engineers and clinicians and will be part of the Edinburgh Computational Biomechanics Group: https://ecbm.eng.ed.ac.uk/home
To Apply: https://www.eng.ed.ac.uk/studying/postgraduate/research/phd/predicting-fracture-risk-metastatic-bone-disease-combined-finite
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