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Predicting remission and recovery in patients with heart failure using high-dimensional targeted and untargeted omics data analysis


Project Description

Heart failure (HF) is an increasingly common worldwide problem and has a high mortality and morbidity, with prognosis worse than some common cancers. Evidence-based treatment improves outcomes, but there is heterogeneity in response to treatment. Many patients continue to deteriorate whilst up to 10% of patients will enter a remission phase where they have few symptoms and very low mortality or hospitalisation rates. Some of these patients may even recover. This project aims to examine this unique group of patients who improve, to discover what pathways or biological processes are involved in remission of HF. It may then be possible to design novel therapies targeted to those pathways to improve HF prognosis.

This project will provide training in blood plasma analysis of a well-characterised HF cohort recruited in an EU-FP7 Programme (BIOSTAT-CHF). The student will learn about sample analysis on high-definition mass spectrometers, and subsequent data processing using bioinformatics. The training will predominantly be based at the newly refurbished Leicester Van Geest MultiOmics facility, which is very well equipped with high-definition discovery mass spectrometers and instruments for targeted analysis. Some training may take place in the Wilmslow laboratories of the industrial partner, Waters Corporation to provide laboratory and business experience.

Entry requirements:
You must hold (or be about to obtain) a First or an Upper Second Class UK undergraduate degree or an equivalent degree from a recognised EU institution, in an area relevant to the projects you are applying for.

Qualifications (or a combination of qualifications and experience) which demonstrate equivalent ability and attainment will also be considered.

For example, a less than sufficient first degree may be enhanced to meet the requirements by the acquisition of a Distinction at Masters level or significant research experience gained from employment).

Informal enquiries:
If you have any questions or would like to find out more about IMPACT, please get in touch.
Email us at

Eligibility:
UK/EU applicants only

To apply:
Please refer to https://more.bham.ac.uk/mrc-impact/phd-opportunities/

Funding Notes

The Studentship provides 3.5 years of Stipend at UKRI rates and Tuition fees at UK/EU rates.

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