KEYWORDS:
Pharmaceuticals, manufacture, polymers, materials science, modelling, 3D printing, extrusion, formulation.
CMAC is a world leading medicines manufacturing research center that hosts a portfolio of collaborative research programs aimed to transform the development and manufacture of medicines (www.cmac.ac.uk). Building on our long-standing partnerships with a wide range of pharmaceutical manufacturers, technology providers and leading universities, we are excited to announce a new EPSRC International Centre to Centre project on Digital Design and Manufacture of Amorphous Pharmaceuticals (DDMAP) EP/W003295/1.
This exciting new international collaboration between the Universities of Strathclyde, Copenhagen and the Technical University of Ghent, will address key research questions. In particular, those that underpin the selection, production and application of amorphous molecular solids in medicines development and manufacture. Working collaboratively, the key DDMAP objectives are to deliver a suite of predictive tools that cover the structure and stability of materials and their transformations during manufacturing processes. This will help improve our understanding of amorphous systems during drug release. Further objectives for the project include developing best practices around collaborative research, data sharing and training. The project provides excellent opportunities for PhD candidates to gain experience of international collaborations through an exchange program between partners. It will also provide opportunity to engage with industry partners supporting the project.
We are currently seeking applicants for a PhD candidate based at the University of Strathclyde. The successful candidate will have a good first degree in a relevant subject (chemistry, materials science, physics, pharmaceutical science, chemical engineering or a related discipline). This component of the broader project will develop predictive methodologies/models and tools for right-first-time amorphous pharmaceutical processing via Hot Melt Extrusion (HME). There will be subsequent dose form processing steps including compression and 3D printing. The successful candidate will exploit advanced continuous processing and analytical capabilities available across all three partners to investigate transformations and stability of amorphous materials during key secondary processing steps. For example, formulation, extrusion, milling, compaction and additive manufacturing.
You must have excellent verbal and written communications skills to engage with partners across the project and have the ability to write clearly and succinctly for publication. Team working will be essential, however the ability to manage time commitments and prioritise individual tasks is also important. You should be able to independently develop new concepts in your research, have excellent organisational skills, initiative, and the ability to pay close attention to detail.
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