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Predictor of fluorosis: total fluoride intake or subsequent fluoride absorption?


Project Description

Research rationale:
To recommend and establish a dietary reference value (DRV) for any nutrient, it has been advocated to adjust this value (i.e., DRV) by “factors to compensate for incomplete utilization and to encompass the variation both in the requirements among individuals and in the bioavailability among the food sources of the nutrient.”
Adequate intake (AI) and tolerable upper intake level (UL) values are the terminologies which have been considered and defined by several international organisations, such as the US Institute of Medicine (IoM), the European Food and Safety Authority (EFSA), and the Australian National Health and Medical Research Council (NHMRC), as guidelines to influence public health policy when adjusting fluoride intake.
Scientific studies looking at the influence of fluoride intake on the risk of fluorosis should therefore include the rate of absorption into the risk model.
One of the recommendations/conclusions of the “San Francisco Fluoride Symposium - 2017” was:
“The field of fluoride metabolism, focusing on overall fluoride bioavailability/absorption and fluoride biomarkers combined with clinical studies, merits new research initiatives to provide more evidence-based data to inform DRVs for fluoride.”

Aims:
Due to the lack of relevant data, the aims of this project are to assess the bio/availability of fluoride from different sources; and its association with some health outcomes (e.g. development of dental fluorosis and bone mass density).

Application Web Page

Applicants must apply using the online form on the University Alliance website at https://unialliance.ac.uk/dta/cofund/how-to-apply/. Full details of the programme, eligibility details and a list of available research projects can be seen at https://unialliance.ac.uk/dta/cofund/


The final deadline for application is 12 April 2019.

Funding Notes

DTA3/COFUND participants will be employed for 36 months with a minimum salary of (approximately) £20,989 per annum. Tuition fees will waived for DTA3/COFUND participants who will also be able to access an annual DTA elective bursary to enable attendance at DTA training events and interact with colleagues across the Doctoral Training Alliance(s).

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 801604.

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