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Preventing infection to promote skin wound healing (GAVRILOVICU20DART)


School of Biological Sciences

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Dr J Gavrilovic , Dr M Webber No more applications being accepted Funded PhD Project (European/UK Students Only)

About the Project

This is an exciting project arising from a new collaboration between Drs Jelena Gavrilovic (Norwich Skin Platform, School of Biological Sciences, UEA https://www.uea.ac.uk/norwich-skin-platform/about) and Mark Webber (Quadram Institute of Biosciences https://quadram.ac.uk/mark-webber/) and GAMA Healthcare.

Infection of skin wounds is a major barrier to healthy wound healing in the ageing population and in diabetes. These
chronic skin wounds are susceptible to bacterial infection and in certain circumstances, the infection spreads and can result in lower limb amputation. Preventing infection of skin tissue of healing wounds is thus paramount. Here you will develop and extend a human skin biopsy “wound healing” model we recently established (within Norwich Skin Platform) to mimic infection under disease conditions and to explore re-epithelialisation and resident immune cell responses to bacteria and products which may be beneficial to wound healing.

You will receive training in extensive human biopsy/cell culture and analytical methods (transcriptomics, proteomics,
imaging), molecular microbiology and bacterial genome analysis. You will have an exciting 3-month placement at the Fellows Research Centre where you will learn techniques for making anti-infection compounds and within GAMA Healthcare HQ where you will have the opportunity to interact with colleagues across all sectors of the company.

Informal enquiries welcome to Jelena Gavrilovic: [Email Address Removed]

This project is funded by the MRC Doctoral Antimicrobial Research Training Programme (DART). Shortlisted applicants can expect to be interviewed on 13th or 14th August 2020. Formal invitations to interview will be circulated by no later than 10th August 2020.

The MRC DART Management Board approves entry to the programme and studentship offers. Offer letters will be sent to successful candidates as soon as possible after the interview date, usually within 10 working days.

Students will benefit from collaborative training with the Norwich Research Park Doctoral Training Programme, as well as a breadth of training possibilities across UEA and Norwich Research Park partners.

Through collaboration with a non-academic partner, iCASE students will spend 3-18 months on a placement with the partner company. Through this placement, students gain access to training, facilities and expertise not available in an academic setting alone, significantly enhancing future employability.

Applicants must meet the minimum eligibility requirements as specified by UKRI-MRC, as well as the entry requirements for UEA postgraduate research degrees. For further information and to apply visit: https://www.uea.ac.uk/study/postgraduate/research-degrees/phds-and-studentships/dart-mrc-icase

For more information on the supervisor for this project, please go here: https://www.uea.ac.uk/norwich-skin-platform

This is a PhD programme.

The start date of the project is 1 October 2020.

The mode of study is full-time. The studentship length is 3.5 years.

Entry requirements

Applicants for DART MRC iCASE studentships must have obtained (or be about to obtain), a First or Upper Second-class UK Honours degree, or qualifications gained outside the UK that are considered to be equivalent, in an appropriate area relevant to their proposed field of research. Applicants with a Lower Second-class degree will be considered if they also have a Master’s degree, or have significant relevant additional non-academic experience. Studentships awarded based on predicted grades will be conditional upon final results.

If English is not their first language, applicants must also meet the University’s English language requirements. Details of English Language requirements for candidates for research degrees can be found on the UEA website.


Funding Notes

In general, funding is available to UK and EU nationals who have established UK or EU residency. For funding eligibility guidance, please visit our website : https://www.uea.ac.uk/study/postgraduate/research-degrees/phds-and-studentships/dart-mrc-icase.

Full studentships are for 3.5 years and cover a stipend (2020/1 UKRI rate: £15,285pa plus iCASE enhancement: £2,500pa), research costs and tuition fees at UK/EU rate and are available to candidates who meet the UK residency requirements.

Candidates from EU countries who do not meet the UK residency requirements may be eligible for a fees-only award if they meet the EU residency requirements.
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