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Probiotic Bacillus

  • Full or part time
  • Application Deadline
    Sunday, April 28, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Aerobic spore-forming bacteria play an important role in promoting gut health. They are used commercially worldwide as dietary supplements, nutraceuticals and cosmoceuticals. SporeGen has an active program in developing new and highly innovative strains of Bacillus. This project working in the lab of Prof Simon Cutting will develop new probiotic blends of Bacillus that could be used commercially. The primary project aim is to identify strains of Bacillus that can persist in the human GI-tract yet also confer beneficial properties on the gut microbiome including the delivery of antioxidants and antibiotics. The project will include extensive microbiology but will also cover molecular biology (for example, analysis of the gut microbiome by qPCR) and immunology (in analysis of host responses). Lastly, the project will enable interaction with a small but developing SME and the commercial aspects of product development.

To apply please click on the ’visit website’ link

Funding Notes

This is a four year CASE studentship award .The funding provides an annual tax-free living stipend with at the standard RCUK rate with London weighting. The amount is currently at £16,777pa for the 18/19 Academic year.

References

Huynh A. Hong, William T. Ferreira, Siamand Hosseini, Saba Anwar, Krisztina Hitri, Anthony J. Wilkinson, Wilfried Vahjen, Jürgen Zentek, Mikhail Soloviev, & Simon M. Cutting. (2017) The Spore Coat Protein CotE Facilitates Host Colonisation by Clostridium difficile. J. Infect. Diseases. 16:1452-1459. PMID: 28968845

Huynh A. Hong, Krisztina Hitri, Siamand Hosseini, Natalia Kotowicz, Donna Bryan, Fatme Mawas, Anthony J. Wilkinson, Annie van Broekhoven, Jonathan Kearsey & Simon M. Cutting. (2017) Mucosal Antibodies to the C-terminus of Toxin A Prevent Colonization of Clostridium difficile. Infection & Immunity. 85:e01060-16. PMID:28167669

Ian J. Passmore, Marine Letertre, Mark D. Preston, Irene Bianconi, Fauzy Nasher, Huynh A. Hong, Simon Baines, Simon M. Cutting, Jon Swann, Brendan W. Wren and Lisa F. Dawson (2018). Para-cresol production by Clostridium difficile affects the composition of the microbiota and contributes to disease. PLOS Pathogens. 14:e1007191

How good is research at Royal Holloway, University of London in Biological Sciences?

FTE Category A staff submitted: 24.00

Research output data provided by the Research Excellence Framework (REF)

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