Profiling miRNA expression in acute anterior uveitis
Prof C Murphy
Dr J Gabhann
Monday, December 02, 2019
Competition Funded PhD Project (Students Worldwide)
Uveitis involves acute, recurrent or chronic inflammation of the uveal tract, the middle vascular layer of the eye. Anterior uveitis (AU), which occurs within the anterior chamber of the eye, is a frequent presentation to ophthalmologists. Acute symptoms of pain, redness and photophobia are very debilitating for the young, working-age group of patients it mostly affects. AU is known to be associated with a variety of systemic conditions, in particular spondyloarthritis (SpA), which affects approximately 40% of cases. AU is characterised by the influx of inflammatory cells into the anterior chamber of the eye, which can be appreciated clinically using the slit lamp microscope. Current knowledge of the mechanisms controlling this pathogenic process is limited. Topical corticosteroids are the cornerstone of therapy in AU. Their precise mechanism of action is poorly understood and they can have a wide array of side effects in the eye. A greater understanding of the pathogenesis of AU is required for the development of more effective and targeted therapies. This project proposes a multidisciplinary approach to investigating the contribution of microRNAs to the molecular pathogenesis of AU.