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Programming the subcellular localization of enzyme inhibitors

Project Description

The generation of enzyme isoform-specific inhibitors is a major challenge for medicinal chemists. In this project, you will take an alternative approach to this challenge to develop spatially-targetted inhibitors. Many of the enzymes are localized to particular compartments in the cell, by delivering the inhibitor to each compartment you will develop a general strategy to make spatially-selective inhibitors. Using oligosaccharide biosynthesis and tailoring the Golgi as a model you will use a combination of synthetic chemistry, protein chemistry and cell biology to develop small-molecule-protein hybrids and test their function in a cellular context. Methods to be used include bioconjugate chemistry as well as advanced cell biological methods, such as mammalian cell culture, fluorescence microscopy and mass spectrometry.

Find out more about the group at our website:

Funding Notes

White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology
4 year fully-funded programme of integrated research and skills training, starting Oct 2019:
• Research Council Stipend
• UK/EU Tuition Fees
• Conference allowance
• Research Costs

At least a 2:1 honours degree or equivalent. We welcome students with backgrounds in biological, chemical or physical sciences, or mathematical backgrounds with an interest in biological questions.
EU candidates require 3 years of UK residency in order to receive full studentship

Not all projects advertised will be funded; the DTP will appoint a limited number of candidates via a competitive process.

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How good is research at University of Leeds in Chemistry?

FTE Category A staff submitted: 34.40

Research output data provided by the Research Excellence Framework (REF)

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