About the Project
Our approach to the treatment of mitochondrial dysfunction is to target the discovery of chemical entities of structural types unknown to metabolic, degenerative, and hyperproliferative diseases. We operate a medicinal chemistry platform based upon Property (parameter) based Fragment Design principals. At a practical level, this strategy is supported by novel chemical flow and microwave technologies allowing us to utilize novel chemical approaches and maximize our efficiency of chemical target synthesis. The strength of this approach is enhanced by a strong multidisciplinary interaction with cell biology, pharmacology and pharmaceutics capabilities within the School of Pharmacy and established collaborations with internal and mitochondrial disease external experts.
This Graduate position will lead to a Ph.D. and allow the successful applicant to acquire and develop their laboratory skills in both microwave and flow chemistry, undertaking the synthesis of novel chemical entities targeted at mitochondrial dysfunction. In addition, the successful applicant will be expected to develop their skills in computer aided rationale design techniques directed towards the rational design of a new generation of mitochondrial therapeutic agents.
Successful candidates will benefit from full technological and academic support from the Medicinal Chemistry Group within School of Pharmacy. They will be encouraged to actively participate in the national and international conferences on mitochondrial disease and also gain training and support by being an active member of the School of Pharmacy and Biosciences Institute. Moreover, during the course of this training, with a support from the University, candidates will develop professional skills (leadership, time management etc.) that will strengthen their future career progression both within and outside the academia.
Applicant should hold or expect to hold a 2:1 or 1st class degree.
If you are interested in applying, send your CV and covering letter detailing your reasons for applying for this studentship to Postgraduate Student Coordinator at School of Pharmacy at firstname.lastname@example.org
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