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Protac-mediated phospholamban ablation - A Chemical Biology approach to the treatment of heart failure


   College of Medicine, Veterinary and Life Sciences

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  Dr Will Fuller, Dr David France  No more applications being accepted  Funded PhD Project (UK Students Only)

Glasgow United Kingdom Cell Biology Synthetic Chemistry

About the Project

Supervisors 

Dr Will Fuller

Dr David France

Project summary:

Heart failure is one of the world’s biggest killers. In this multidisciplinary PhD project, you will work across two labs to bridge the divide between cardiovascular science and chemistry. We have identified a new strategy that could potentially be used to treat heart failure that relies on targeted protein degradation, an emerging strategy in medicinal chemistry. In this project, you will make a new set of small molecules called proteolysis targeting chimeras (PROTACs) and test them for efficacy against phospholamban, a key regulator of cardiac function. Knowledge of both cell biology and synthetic chemistry is essential, with experience in both a further positive.


Funding Notes

The studentship provides funding for tuition fees, a stipend and laboratory expenses for Home (UK) applicants only.
The MVLS/EPSRC grant provides tuition fees and stipend of at least £15,285 (UKRI rate 2020/21).
Please view application information here: https://www.gla.ac.uk/colleges/mvls/graduateschool/mvlsepsrcstudentships/
Once you have all the required application documentation, please apply here: https://www.gla.ac.uk/study/applyonline/?CAREER=PGR&PLAN_CODES=ZY38-7316
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