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Protein engineering of protein switches for development of diagnostics tools

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Sensitive and specific detection of serum antibodies is often used to diagnose infections. This project aims to develop a simple qualitative/quantitative device for detection of antibodies of interest. It will involve protein engineering of protein switches to incorporate antigens. Binding of the antibodies to the antigens will activate the protein switch which will result in release of a signal.

Funding Notes

About the scholarship

The 2019 Griffith University Postgraduate Research Scholarship has an annual stipend of $27,596 (indexed) for a period of up to three years of full-time study. Please see the GUPRS Conditions of Award for more information: View Website

A successful International applicant will also be awarded a Griffith University International Postgraduate Research Scholarship to cover tuition fees for up to three years. Please see the GUIPRS Conditions of Award for more information: View Website

References

1. Rehm, B. H. A. et al., Self-Assembled Protein-Coated Polyhydroxyalkanoate Beads: Properties and Biomedical Applications. ACS Biomaterials Science & Engineering 2017, 3 (12), 3043-3057.

2. Brockelbank, J. A.; Peters, V.; Rehm, B. H. A., Recombinant Escherichia coli Strain Produces a ZZ Domain Displaying Biopolyester Granules Suitable for Immunoglobulin G Purification. 2006, 72 (11), 7394-7397.

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