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Protein Modification for rapid DNA repair.


Project Description

Applications are invited for a 4-year fully-funded/self-funded PhD Studentship starting October 2020.


In order to respond to DNA damage or to blocked replication our cells use post translational modifications. These act to rapidly change the repertoire of functions to already present proteins thereby acting quicker than the generation of new proteins might be. We are interested in the way that these modifications act to change protein function to help DNA repair and to overcome problems in DNA replication. We are offering a CR-UK funded research project to investigate the interplay between important post-translational modifications to address how they act to change protein function. These changes may be critical to the prevention of cancer development and to the say our cells respond to chemotherapies.


Person Specification
Applicants should have a strong, demonstrable, background in biochemistry. They should be able to demonstrate prior competence in a laboratory environment and hold or realistically expect to obtain at least an Upper Second Class Honours Degree in Biochemistry, or in Biology having options in biochemistry or in a Biophysics-related subject.
How to apply
Informal questions should be directed to Prof Morris: . Applications should be directed to David Piela: .
To apply, please send:
• A Detailed CV, including your nationality and country of birth;
• Names and addresses of two referees;
• A covering letter highlighting your research experience/capabilities;
• Copies of your degree transcripts;
• Evidence of your proficiency in the English language, if applicable.

Applicants will be required to attend an interview in February. This will include meeting the research group and a tour of the lab’s. While the interview can be conducted by telephone or skype, face –to –face is ideal

Funding Notes

This PhD is funded by Cancer Research UK and includes bench fees, tuition fees and a living stipend ~£19,000 pa.

The position is open to UK and EU nationals.

References

Relevant references from the lab: Daza-Martin et al (2019) Isomerization of BRCA1-BARD1 promotes replication fork protection. Nature, 571, 521-527. (2019) Garvin et al (2019). The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms. Genes Dev, 33, 333-347.

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