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Protein-protein interactions in the pantothenate biosynthetic pathway


   Faculty of Biological Sciences

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  Dr M E Webb, Dr A Pearson  No more applications being accepted  Competition Funded PhD Project (European/UK Students Only)

About the Project

Protein-protein interactions are critical to the function of many signaling pathways. Their importance in the regulation of central metabolism is less well studied, however PPIs can serve to modulate the catalytic activity of enzymes. In this project you will investigate the structural basis for interactions with enzymes of the pantothenate biosynthetic pathway previously identified via high-throughput screening. You will use a combination of approaches including fluorescence, calorimetry, X-ray crystallography and small angle X-ray scattering to define the shape and affinity of the complexes in solution and then assay the biochemical consequences of their formation.

Funding Notes

4 year BBSRC studentship, under the White Rose Mechanistic Biology DTP.
The successful applicant will receive fees and stipend (c.£13590 for 2013-14). The PhD will start in Oct 2013.Applicants should have, or be expecting to receive, a 2.1 Hons degree in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support.
There are 2 stages to the application process. Please see our website for more information:
www.fbs.leeds.ac.uk/gradschool/keywords/mnuFindaphd.php

References

Formation of a heterooctameric complex between ADC and its cognate activating factor, PanZ, is CoA-dependent Diana C.F. Monteiro, Michael D Rugen, Dale Shepherd, Shingo Nozaki, Niki Hironori and Michael E Webb Biochem. Biophys. Res. Commun. (2012) 426, 350-355

An activator for pyruvoyl-dependent L-aspartate alpha-decarboxylase is conserved in a small group of the gamma-proteobacteria including Escherichia coli Shingo Nozaki, Michael E Webb and Niki Hironori MicrobiologyOpen (2012) 1, 298-310
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