Protein structure, molecular mechanisms and human genetic disease: beyond the loss-of-function paradigm

A 3.5-year funded PhD studentship in computational biology is available to join the Marsh lab(https://www.ed.ac.uk/mrc-human-genetics-unit/research/marsh-group) at the MRC Human Genetics Unit, University of Edinburgh to work on the ERC Consolidator Grant research programme PROT-STRUCT-DISEASE.

Advances in structural biology and the computational prediction of protein structures means that we are now able to study the molecular effects of human mutations on an unprecedented scale. Potential PhD projects are available for various aspects of this research programme, including structural bioinformatics analyses of different types of disease mutations, investigation into how protein complex stoichiometry and assembly can influence the phenotypic effects of mutations, and analysis of deep mutational scanning and variant effect predictor datasets. Interested students are encouraged to contact Dr Joe Marsh ([Email Address Removed]) with any questions and to discuss project details.

Applicants should hold at least an upper second-class degree in a relevant subject and comply with English language requirements (https://www.ed.ac.uk/studying/postgraduate/applying/your-application/entry-requirements/english-requirements).