About the Project
In this PhD you will learn, utilise and develop HS-AFM height spectroscopy techniques with the aim to push past current experimental limits to study molecules including proteins at previously inaccessible time and length scales. To perform these experiments, you will develop new algorithms and analysis methods and apply theory and computation to obtain quantitative information about kinetic behaviour at the single molecule level. You will apply these methods to answer a number of possible biophysical and biomedical questions with researchers across multiple fields including Medicine, Biology, Physics and Chemistry.
1. Heath, G. R., & Scheuring, S. (2018). High-speed AFM height spectroscopy reveals µs-dynamics of unlabeled biomolecules. Nature communications, 9(1), 1-11.
2. Matin, T. R., Heath, G. R., Huysmans, G. H., Boudker, O., & Scheuring, S. (2020). Millisecond dynamics of an unlabeled amino acid transporter. Nature Communications, 11(1), 1-11.
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