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Pushing the Speed Limits of High-Speed Atomic Force Microscopy


Faculty of Engineering and Physical Sciences

About the Project

Understanding the structural dynamics of complex molecules is vital to advancing our knowledge of materials, medicine and diseases, yet there are few techniques which can capture motions at high enough speeds or resolution to understand the underlying behaviour. High-Speed atomic force microscopy (HS-AFM) allows us to video, with sub-nanometre resolution, molecules in action at >10 frames per second whilst in liquid environments. However, many important dynamics occur much faster than this, the newly developed height spectroscopy mode of AFM allows motions to be measured at 100,000 times per second. The height spectroscopy method can be applied to study the diffusion of many molecules or the structural dynamics of an individual molecule.

In this PhD you will learn, utilise and develop HS-AFM height spectroscopy techniques with the aim to push past current experimental limits to study molecules including proteins at previously inaccessible time and length scales. To perform these experiments, you will develop new algorithms and analysis methods and apply theory and computation to obtain quantitative information about kinetic behaviour at the single molecule level. You will apply these methods to answer a number of possible biophysical and biomedical questions with researchers across multiple fields including Medicine, Biology, Physics and Chemistry.

Funding Notes

A highly competitive Joint School of Physics & Astronomy/Biomedical Sciences Scholarship award paying Academic Fees and Maintenance matching EPSRC rate of £15,285 per year for 3 years. 

References

References:
1. Heath, G. R., & Scheuring, S. (2018). High-speed AFM height spectroscopy reveals µs-dynamics of unlabeled biomolecules. Nature communications, 9(1), 1-11.
2. Matin, T. R., Heath, G. R., Huysmans, G. H., Boudker, O., & Scheuring, S. (2020). Millisecond dynamics of an unlabeled amino acid transporter. Nature Communications, 11(1), 1-11.

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