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QUADRAT DTP: Actions of early life endocrine-disrupting chemical exposure on adult fish health using the zebrafish model


   QUADRAT

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  Prof S Martin, Prof G Hardiman  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Landfills and other legacy waste sites in coastal zones are major sources of persistent organic pollutants (POPs), including polychlorinated biphenyl (PCBs), Perfluoroalkyl substances (PFASs) and polybrominated diphenyl ethers (PBDEs), to transitional waters and marine environments. Recent evidence suggests that the impact and up take of these is exacerbated by the massive amount of microplastics that exist, especially in the aquatic environment. To date research on environmental pollutants have used have examined complex mixtures of contaminants in the wild, or when carried out in laboratory setting have focused on pharmacological levels rather than those that might occur in the environment. ‘One Health’ is an emerging paradigm that recognizes that the health and well-being of humans, animals and ecosystems are all interconnected. The long-term release, durability and persistence of POPs in the environment has allowed their accumulation in freshwater and marine environments

The project fits directly within both the theme Environmental Management specifically “Environmental physiology” and “Ecotoxicology” especially “Impacts of land/ sea use”, The impact of acute and chronic exposure to man-made POPs is a major environmental concern, with the legacy of historic landfills still leaching into the environment.

The long-term outcome of POPs in fish is poorly understood, especially in the context of host health and resilience to pathogen challenges – with increasing pathogens being present due to environmental change.

This project will use zebrafish as a model to examine how early life exposure to POPs known to be associated with microplastic impact both endocrine and immunological development. The development of both the innate and adaptive immune system is central to the capacity of an animal to respond to infective agents. The final outcomes of the PhD will be to assess how early life toxin exposure may perturb immunological development as an adult onset disease. This research is highly relevant to NERC outputs and coalesces expertise in zebra fish, genomics, bioinformatics and immunology. Transgenic lines of zebrafish with labelled macrophages and neutrophils will enable cellular localisation of immune responses and how these are altered by POP exposure. To explore deeper mechanisms involving genome and chromatin architecture ChIP-seq and ATAC-seq approaches (general known as epigenetics) will reveal activated and inactive regions of the genome.
Training: the student will be based at University of Aberdeen (Prof. Samuel Martin), Scottish Fish Immunology Research Centre, and co supervised with Queens University of Belfast, Institute for Global Food Security (Prof. Gary Hardiman), exposures will be carried out in the state of the art zebrafish facility in University of Aberdeen.

The project’s multidisciplinary approach provides an excellent opportunity for training in various aspects of aquatic biology and advanced environmental and risk assessment analysis. Moreover, it provides an exceptional opportunity for research training in both Northern Ireland and Scotland whereby the successful candidate will work collaboratively across disciplines and research cultures to generate new insights that transcend traditional boundaries. The project will combine aspects of marine biology, environmental chemistry, genetics, bioinformatics and systems biology. Consequently, subject-specific training will be offered in each of these areas. This will comprise a mix of appropriate postgraduate level training (e.g. molecular biology, bioinformatics, genetics, biogeochemistry, computer science, environmental change) and ‘hands on’ training in the advanced systems level methods used.

More project details are available here: https://www.quadrat.ac.uk/projects/actions-of-early-life-endocrine-disrupting-chemical-exposure-on-adult-fish-health-using-the-zebrafish-model/

How to apply: https://www.quadrat.ac.uk/how-to-apply/

Funding Notes

QUADRAT studentships are open to UK and international candidates (EU and non-EU). Funding will cover UK tuition fees/stipend/research & training support grant only.

Before applying please check full funding and eligibility information: https://www.quadrat.ac.uk/funding-and-eligibility/
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