QUADRAT DTP: Identifying Environmental Factors for Soil Transmitted and Food Borne Helminth Diseases in Border Regions of Northern Thailand

Parasitic worm infections (helminthiases) of humans greatly impact low to medium income countries such as Thailand, by undermining health and agricultural productivity. Particularly across Southeast Asia, the expansion of urban areas and the movement of people from countries with less developed public health programs, have increased disease transmission. This project will investigate environmental influences on helminth disease transmission. Many emerging helminthiases are linked to the environment through increased contact between humans and animals, the intensification and integration of food production systems, and the expansion of migration [1]. Therefore, effective control and treatment of many helminth diseases would benefit from better integration of clinical, veterinary and agricultural components embedded in an environmentally-driven research strategy.

Thailand is classified as an “Upper Middle Income” country. However, due to the nature of helminth diseases endemic sites are significantly impacted by border countries including Cambodia, Laos and Myanmar, all of which are classified as “Least Developed” countries. Our research team has recently established baseline human infection rates in three Thailand border regions, using highly sensitive molecular diagnostics. In the past the under-estimation of helminth infections in communities such as Thailand and our previous work in the Philippines [2], provides incomplete information for the development of government policy.

The proposed project will use already established human prevalence data to focus on specific locations and parasite species in endemic regions of Northern Thailand, so that environmental components of disease transmission can be identified. One class of parasites, soil transmitted helminths (STH), requires significant environmental contamination for effective disease transmission. Approximately 1.5 billion or 25% of the world population, are infected by STH, including the main species of Ascaris, Trichuris and hookworm. Parasite eggs found in the soil or unwashed vegetables are the primary source of infection [3]. Similarly, food borne diseases, including the cancer-causing Opisthorchis, are contracted by consuming uncooked fish, and are linked to water sources, and the interaction between snail and fish hosts.

The student will spend considerable time in Thailand, collecting soil, vegetable and aquatic samples for diagnostics using traditional microscopy and more recently developed molecular analysis. Environmental foci of disease will be stratified using spatial modelling (GIS geographical information system) to demonstrate the importance of food and geography in helminth disease transmission. Earth observation data will be used to build GIS layers of climatic and other relevant environmental factors, and enable intervention strategies to be assessed against likely future changes. Identification of environmental components of disease transmission will lead to predictive models for better informed government control policies.

Start date:

1 October 2020

Duration:

42 months

Eligibility:

Candidates should have (or expect to achieve) a minimum of a 2.1 Honours degree in a relevant subject. Applicants with a minimum of a 2.2 Honours degree may be considered providing they have a Distinction at Master’s level.

Application procedure:

• Apply for Degree of Doctor of Philosophy in Biological Sciences at Queen’s University Belfast
• State name of the lead supervisor as ‘Name of Proposed Supervisor’ on application
• State ‘QUADRAT DTP’ as Intended Source of Funding
• Select ‘Visit Website’ to apply now