About the Project
This study will examine the role that TE played in facilitating the colonisation of the deep oceans by the amphipod crustacea. Few metazoan species managed to evolve the capacity to cope with the extreme environmental conditions associated with life at full ocean depth. Those that did tend to have large genomes consistent with the proliferation of TE, and some key genetic adaptations in deep sea animals are also clearly associated with previous TE activity.
The latest advances in DNA sequencing technology are, for the first time, providing opportunities to examine the genome-wide effects of TE on gene content and structure, and a hosts capacity to police and so understand the mechanics of how TE may have driven evolution and adaptation during the colonisation of the deep sea.
The project will use the very latest DNA sequencing approaches in a unique sample set of deep sea amphipods collected from across the World’s oceans to: 1) compare and contrast the diversity, location, activity and abundance of TE in deep versus shallow water species; 2) examine the evolutionary history of transposition across the phylogeny of deep sea amphipods; 3) link TE activity to genes that affect fitness to deep ocean conditions and so shaped adaptation and evolution in the deep sea; 4) characterise levels of DNA CpG methylation in deep sea amphipods to examine capacity to affect TE activity.
This lab-based project offers outstanding training opportunities in state-of-the-art ‘omics approaches and bioinformatic and evolutionary analyses, coupled with a programme of broad core and generic skills development that is central to the Quadrat DTP training programme. The student will become part of a dynamic and vibrant multidisciplinary postgraduate community, and have the opportunity to make a major contribution to our understanding of fundamental issues in both evolutionary biology and deep sea ecology and biogeography. The project would suit a student with a background and interests in molecular marine biology, evolution and genetics. Previous training and experience in the use of DNA markers to answer questions in ecology and evolution is desirable but not essential.
More project details are available here: https://www.quadrat.ac.uk/projects/the-role-of-transposable-elements-in-driving-evolution-and-adaptation-in-the-deep-sea/
How to apply: https://www.quadrat.ac.uk/how-to-apply/
Before applying please check full funding and eligibility information: https://www.quadrat.ac.uk/funding-and-eligibility/
Jamieson, AJ, Malkocs, T, Piertney, SB, Fujii, T & Zhang, Z 2017, 'Bioaccumulation of persistent organic pollutants in the deepest ocean fauna', Nature Ecology & Evolution, vol. 1, 0051 .
Ritchie, H, Jamieson, AJ & Piertney, SB 2017, 'Genome size variation in deep-sea amphipods', Royal Society Open Science, vol. 4, 170862, pp. 1-9.
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