Viral infection by human rhinovirus (HRV) is now accepted to occur in early childhood in people with Cystic Fibrosis (PWCF). As such, HRV
is now thought to contribute to the pathogen burden in childhood in CF and contributes to inflammation in the early CF lung. The lesson from
other diseases such as chronic obstructive pulmonary disease (COPD) is that infection with HRV can contribute to secondary bacterial infection in that disease – bacterial infection is also a significant feature of CF lung disease. In this study, we will use a combination of primary
human CF cell models and in vivo CF models to understand further how viral infection may contribute to bacterial infection in early CF and
set up the conditions for chronic infection and sustained inflammation in this disease. We will also obtain samples from PWCF who are being
treated with CFTR modulator therapy to determine if modulator treatment can restore/normalise the anti-viral and antimicrobial
The successful student will join a strong CF research group funded by the MRC, NIHR, EU-H2020 and CFF and will learn a wide
range of cell culture and in vivo techniques and be encouraged to present their findings at national and international meetings.
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.