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Queen's DTP: The role of viruses in the establishment of chronic bacterial infection in early Cystic Fibrosis lung disease


School of Medicine, Dentistry & Biomedical Sciences

, Thursday, February 11, 2021 Competition Funded PhD Project (Students Worldwide)

About the Project

Viral infection by human rhinovirus (HRV) is now accepted to occur in early childhood in people with Cystic Fibrosis (PWCF). As such, HRV

is now thought to contribute to the pathogen burden in childhood in CF and contributes to inflammation in the early CF lung. The lesson from

other diseases such as chronic obstructive pulmonary disease (COPD) is that infection with HRV can contribute to secondary bacterial infection in that disease – bacterial infection is also a significant feature of CF lung disease. In this study, we will use a combination of primary

human CF cell models and in vivo CF models to understand further how viral infection may contribute to bacterial infection in early CF and

set up the conditions for chronic infection and sustained inflammation in this disease. We will also obtain samples from PWCF who are being

treated with CFTR modulator therapy to determine if modulator treatment can restore/normalise the anti-viral and antimicrobial

response.

The successful student will join a strong CF research group funded by the MRC, NIHR, EU-H2020 and CFF and will learn a wide

range of cell culture and in vivo techniques and be encouraged to present their findings at national and international meetings.


Funding Notes

There are a number of competition based studentships available, funded by the Department for the Economy (DfE). These opportunities are primarily available for UK applicants but there will be a small number of awards available for EU/international candidates.

References

Please visit the QUB website for further information about the Wellcome-Wolfson Institute for Experimental Medicine https://www.qub.ac.uk/research-centres/wwiem/
Applications are made via our Direct Applications Portal https://dap.qub.ac.uk/portal/user/u_login.php

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