Raman probes to determine cellular redox potential

The discovery of novel medicines to treat disease requires the identification, understanding and validation of new biological pathways and targets. This project resides in the Healthcare technologies theme, aligning with the growth area of Chemical Biology and the areas of Analytical Science and Synthetic Organic Chemistry.

Altering the redox environment within a cell can give rise to changes that result in disease. The ability to sense and determine a cellular redox potential would allow for basic biological investigation and the discovery of new targets for drug discovery. We will develop environmentally sensitive Raman active probe molecules capable of determining the redox environment in cells.