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Raman probes to determine cellular redox potential


Project Description

The discovery of novel medicines to treat disease requires the identification, understanding and validation of new biological pathways and targets. This project resides in the Healthcare technologies theme, aligning with the growth area of Chemical Biology and the areas of Analytical Science and Synthetic Organic Chemistry.

Altering the redox environment within a cell can give rise to changes that result in disease. The ability to sense and determine a cellular redox potential would allow for basic biological investigation and the discovery of new targets for drug discovery. We will develop environmentally sensitive Raman active probe molecules capable of determining the redox environment in cells.

Funding Notes

European/UK students with a first degree in Chemistry or related subject

References

Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry. Proc. Nat. Acad. Sci. 2017, 114, E1365-E1374.

A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis. Scientific Reports 2017, 7, 10.

How good is research at University of Strathclyde in Chemistry?
(joint submission with University of Glasgow)

FTE Category A staff submitted: 35.40

Research output data provided by the Research Excellence Framework (REF)

Click here to see the results for all UK universities

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