This project will involve the synthesis and characterisation of new heterocyclic compounds which can act as core scaffolds for drug development. Nucleophilic aromatic substitution reactions will be employed as a quick and reliable transition metal-free method to form new ring structures starting from polyfluorinated arenes. The products are then easily modified to allow SAR studies to be conducted. Compounds prepared will be screened with our partners for activity, particularly as anti-parasitic agents targetting neglected tropical diseases such as Malaria, Sleeping Sickness and Chagas Disease.
The project will give experience of synthetic and mechanistic organic chemistry, and related analytical methods (1H, 13C and 19F NMR, MS, IR) used in structure determination.
Applicants should have, or expect to achieve, at least a 2:1 Honours degree (or equivalent) A relevant Master's degree and / or experience in one or more of the following will be an advantage: - Organic synthesis - Purification of organic compounds - Structure determination - NMR spectroscopy
How to apply
All applications should be made online. Under programme name select School of Science. Please quote reference number: CM/GW-Un1/2019