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Rational design and production of glyco-peptidic inhibitors of pathogens’ adhesion to host cells.

Project Description

The ability of protein molecules to stick to cells is crucial for life and disease. The project is based on a novel concept to design adhesive molecules based on multivalence and entropic stabilisation. The candidate will rationally design, produce and test flexible molecules linking sugars with peptides; linkers will be designed minimise entropy loss upon adhesion and maximise enthalpy gain through non-specific interactions with protein’s surface. The project will be carried out between Paci lab in the School of Molecular and Cellular Biology (rational design and simulation) and Turnbull lab in the School of Chemistry (production and assessment of glycopeptides). A strong physical background is an advantage, as well as programming and lab experience.

Funding Notes

This studentship is funded by Leverhulme Trust for 3 years and can start anytime before the application deadline
• Research Council Stipend
• UK/EU Tuition Fees
• Conference allowance
• Research Costs

Preferably MSc or at least a 2:1 honours degree or equivalent. We welcome students with backgrounds in chemical or physical sciences with an interest in biological questions.

If English is not your first language, you will need a recognised English Language qualification to be admitted onto any of the University's degree programmes: View Website

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

Research output data provided by the Research Excellence Framework (REF)

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