Reaction of brain barriers to chemotherapy

Breakdown of the blood-cerebrospinal fluid (B-CSF) barrier localized in the brain choroid plexus is associated with many neurological disorders. However, relatively little is known about the underlying molecular mechanisms. Alteration of the barrier integrity and its involvement in the initiation and progression of neurological disorders need to be determined to get insights into treatment approaches. Our team focuses on studying the B-CSF barrier in pathophysiological conditions using in-vivo and invitro models and a combination of different techniques. The dissertation thesis aims to investigate the molecular and cellular mechanisms underlying the spread of inflammatory responses through the B-CSF barrier following chemotherapy and its subsequent neuropathy.

Requirements:

• Graduate student of Medical School, Molecular Biology, Biochemistry, or relevant disciplines
• Hands on experiences with WB, PCR, and cell culture
• Active knowledge of English (min. B2)

Information about supervisor:

• Appointed as Assistant professor at Masaryk University-Anatomy Department, Ph.D. and postdoctoral study in Japan, Experienced in electrophysiology and optogenetic, Publications in high-ranked journals
• Collaboration with institutes and academic stages: International collaboration with high-profile laboratories, as well as other faculties of Masaryk University
• Possible stage for the student: Participation in a dynamic and motivated research team, Opportunity to gain expertise in cutting-edge techniques