Reactive Inkjet Printing of Tissue Culture Scaffolds
3D scaffolds with excellent biocompatibility, biodegradability, sophisticated 3D structures and appropriate mechanical properties are particularly desired as in vitro models in biomedical research and are highly attractive in clinical applications (e.g. as nerve guidance conduits) However, fabricating such scaffolds is challenging. In particular, the lack of precise control of 3D structures (e.g. architectures, porosities, pore sizes and vascularity) in scaffolds has become a major challenge due to the lack of advanced fabrication techniques.
This PhD project is to fabricate 3D tissue cultural scaffolds with well-defined architectures using reactive inkjet printing technology with various bio-inks such as silk fibroin, designed self-assembly peptide hydrogels, alginate and chitosan. The student will be trained to use modern techniques such as 3D reactive inkjet printing, AFM, SEM, TEM, FTIR, CD Spectroscopy, Confocal Laser Scanning Microscopy (CLSM) etc. to fabricate the scaffolds and characterize their properties. A combination of relevant cell assays will also be carried out to evaluate the biocompatibility, degradability and biological functions of the fabricated scaffolds.
Applicants should have or expect to gain a first class or upper second-class honours degree (or equivalent if from overseas) in any of the following backgrounds: chemistry, physics, biochemistry, biotechnology, biomaterials, biomedical engineering, pharmaceutics, bioengineering, chemical engineering or a related discipline, or have an appropriate MSc qualification.
If English is not your first language then you must have International English Language Testing Service (IELTS) certificate with an average of 6.5 or above and at least 6.0 in each component.