About the Project
To achieve this aim, scale-down models that enable careful assessment of reactor performance and biocatalysts’ behaviour are necessary. Miniaturized continuous-flow reactors are prime candidates. Their small dimensions allow experiments to be performed with much smaller volumes compared to traditional batch systems, offering significant cost reduction when using expensive substrates or enzymes. Within these reactors the control of reaction parameters is facilitated, and in-line purification with recovery of products has been demonstrated. Additionally, reactions can be potentially accelerated due to enhanced mass transfer with a concomitant decrease in reaction time. Therefore, miniaturized continuous-flow reactors will in the future form the basis to acquire high-quality data rapidly and with high throughput.
• Design, fabricate, and characterize a miniaturized continuous-flow reactor with integrated optical sensors and at-line analytical tools for the on-line monitoring of chemical and physical variables (pH, temperature, oxygen and CO2) and for at line reaction analytics (GC- and LC-MS).
• Validate the integrated miniaturized continuous-flow reactor with industrially relevant biocatalytic reactions.
• Compare the reactor performance in batch and continuous systems (e.g. by space-time yields, (gproduct/(Lreactor.h), and (gproduct/genzyme)) at all scales assessing process stability, quality profile of the products process and scalability.
Output & Impact
This project aligns with UK strategic priorities in the area of Industrial Biotechnology and the departmental EPSRC Future Biomanufacturing Research Hub. Due to the high relevance and timeliness of this research direction, we anticipate that each objective of the project will lead to a publication output. The results obtained throughout this project will be included in teaching of undergraduates or postgraduate modules.
Applicants should have a degree equivalent to a UK first class honours, or a high upper second class, in Engineering or Physical Sciences. This PhD will be multidisciplinary, straddling both biochemical and chemical engineering. The successful candidate should have strong analytical skills and aptitude for biocatalysis, reactor engineering and numerical modelling.
The starting date for this PhD will be 28 September 2020. To apply for this studentship, please send your max. two-page CV and cover letter by email to Dr Marco Marques, project supervisor to arrive no later than 12pm on Monday, 13th July 2020. In addition to this, you must submit your formal application through UCL’s Application portal for the Research Degree: Biochemical Engineering course for 20/21 entry. More information about the application process is available on the department’s website: https://www.ucl.ac.uk/biochemical-engineering/study/postgraduate-research/biochemical-engineering-mphilphd
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
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