This is a 4 year BBSRC CASE studentship under the Newcastle-Liverpool-Durham DTP. The successful applicant will receive research costs, tuition fees and stipend (£15,009 for 2019-20). The PhD will start in October 2020. Applicants should have, or be expecting to receive, a 2.1 Hons degree (or equivalent) in a relevant subject. EU candidates must have been resident in the UK for 3 years in order to receive full support. Please note, there are 2 stages to the application process.
A complex suite of loci and elements in eukaryotic type II topoisomerases determine selective sensitivity to distinct poisoning agents (2019) Nucleic Acids Research 47(15): 8163-8179.
Identification and biosynthesis of thymidine hypermodifications in the genomic DNA of widespread bacterial viruses (2018) Proceedings of the National Academy of Sciences of the United States of America 115(14): E3116-3125.
Evolution of Pectobacterium bacteriophage ΦM1 to escape two bifunctional Type III toxin-antitoxin and abortive infection systems through mutations in a single viral gene (2017) Applied and Environmental Microbiology 83(8): e03229-16.
Novel m4C modification in type I restriction-modification systems (2016) Nucleic Acids Research 44(19):9413-9425.
Structure of type IIL restriction-modification enzyme MmeI in complex with DNA has implications for engineering new specificities (2016) PLoS Biology 14(4): e1002442.
Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis (2016) Proceedings of the National Academy of Sciences of the United States of America 113(7): 1706-1713.
Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase (2016) Proceedings of the National Academy of Sciences of the United States of America 113(7): E839-E846.
Co-evolution of quaternary organization and novel RNA tertiary interactions revealed in the crystal structure of a bacterial protein–RNA toxin–antitoxin system (2015) Nucleic Acids Research 43(19): 9529-9540.
Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot (2013) Proceedings of the National Academy of Sciences of the United States of America 110(3): E241-9.
A processed non-coding RNA regulates an altruistic bacterial antiviral system (2011) Nature Structural and Molecular Biology 18(2): 185-190.