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  Redox signalling in metabolic dysfunction and ageing

   MRC Laboratory of Medical Sciences (LMS)

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  Dr H Cocheme  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

A PhD Studentship (4 years) is available under the supervision of Dr Helena Cochemé (Redox Metabolism Group) at the MRC London Institute of Medical Sciences (LMS). The PhD student will be registered with Imperial College London, and will be based at the vibrant Hammersmith Hospital Campus in West London (W12). We offer a leading multidisciplinary training environment, and benefit from laboratories and facilities in the newly opened state-of-the-art LMS Building.

The successful candidate will use the fruit fly Drosophila as an in vivo model system to explore biological mechanisms behind ageing, focusing on the role of redox signalling. Redox signalling acts as a reversible switch to regulate cellular processes, and operates through the specific post-translational modification of cysteine residues on target proteins, integrating cues from oxidative stress, nutritional status and mitochondrial function. In the Cochemé lab, we use a combination of biochemical, molecular, pharmacological, proteomic and genetic knock-in approaches to gain mechanistic insight into redox signalling in vivo.

Human life expectancy is increasing and populations are ageing, which has important social and economic implications. Ageing is the biggest risk factor for a wide range of pathologies, such as diabetes, neurodegeneration, cancer and cardiovascular disease. However, the ageing process itself is still poorly understood. Through our research, we aim to uncover novel redox-sensitive targets and to develop therapeutic strategies for health and longevity benefits.

The PhD position is available to start from October 2023. To apply for this project, please submit a completed application form to [Email Address Removed]. The form can be downloaded from our website:

Who we are looking for:

• Strong interest in redox biology.

• Master’s degree in a relevant field (e.g. Molecular Biology, Biochemistry, Biomedicine), or Bachelor’s degree plus evidence of laboratory research experience (e.g. internships).

• Excellent verbal and written communication skills in English.

Diversity statement:

Imperial and MRC are committed to advancing equality, diversity and inclusion, and welcomes applications from talented people of all backgrounds.

Lab websites:

To apply for this project please visit the LMS Website ( where an application form can be downloaded for submission and consideration. Please note that only candidates who have submitted a sompleted application form by the deadline will be considered.

Biological Sciences (4)

Funding Notes

This studentship includes a tax free stipend amounting to £25,000pa paid directly to the student for 4 years, as well as covering all tuition fees.


Lennicke & Cochemé (2021) “Redox metabolism: ROS as specific molecular regulators of cell signaling and function” Molecular Cell 81(18), 3691-3707
van Dam et al. … Cochemé (2020) “Sugar-induced obesity and insulin resistance are uncoupled from shortened survival in Drosophila” Cell Metabolism 31(4),710-725
Lennicke & Cochemé (2020) “Redox signalling and ageing: insights from Drosophila” Biochemical Society Transactions 48(2), 367-377
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