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Regenerative treatment of periodontal defects with Guided Tissue Regeneration (GTR) and Autogenous Platelet Concentrate (APC). Characterization of early healing stages through 2D/3D imaging and PROMs

Institute of Dentistry

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Dr E Calciolari , Prof N Donos No more applications being accepted Competition Funded PhD Project (European/UK Students Only)

About the Project

Preparations based on autologous platelet concentrates (APCs) such as plasma rich in growth factors (PRGF) are being increasingly used in regenerative medicine to promote wound healing and tissue regeneration. The possibility of using PRGF as an autologous material for the regeneration of periodontal defects offers pragmatic advantages over the currently available regeneration biomaterials. However, the scientific literature is not conclusive in relation to its clinical and wound healing efficacy.

Background & significance
Periodontitis (gum disease) is a chronic, microbially-driven inflammatory disease of the supporting apparatus of the teeth, which represents the major cause of tooth loss in adult populations and the 6th most prevalent disease worldwide (Kassebaum et al., 2014). In UK, 70% of adults suffer from periodontitis, of which 10% present with severe forms (Adult Oral health survey, 2011). It disproportionately affects the vulnerable segments of the population, it negatively impacts on quality of life and is a source of social inequality (Jepsen et al., 2017; Fuller et al. 2020, Ferreira et al., 2017).

Hypothesis and aims
This investigation aims to describe the early healing events (up to 4 weeks) in terms of 3D/2D volumetric and thermal changes as well as PROMs associated with the regeneration of periodontal intrabony defects performed with GTR or PRGF, both combined with a minimally invasive flap (simplified papilla preservation flap - SPPF).

While this study will assess several additional outcomes as part of a large randomized, singleblind, parallel-group controlled trial (like changes in PPD (primary outcome) and other clinical and radiographic parameters), this PhD thesis will specifically focus on the application of noninvasive 3D/2D imaging technologies to describe the different intra-oral/extra-oral healing patterns during periodontal regeneration and on the characterization of PROMs. More specifically, for this PhD project we will consider the following outcomes:

Primary outcome:
Post-operative swelling, oedema and change in temperature at different early healing time points (from 2 days to 4 weeks after surgical treatment) assessed with the help of 3D intra and extraoral geometrical and 2D Thermal imaging

Secondary outcomes:
Changes in patients’ reported outcomes (PROMs) measured with Global ratings of Periodontal Health and Quality of Life, global changes in quality of life, EuroQol-5D-5L and patient perception about therapy up to 4 weeks post-surgical treatment; - visual assessment of gingival healing and early healing index up to 2 weeks post-surgical treatment.

How to apply
To apply, please click the 'institution website' button.

The successful candidate must be a registered dental clinician in the UK.

Funding Notes

These studentships will fund a student with a clinical qualification and GMC / GDC registration at any career stage below consultant. They will be funded for three years at current, MRC rates. Studentships will include PhD fees (at home/EU levels) and up to £6000 pa for consumables. Further consumables / funding for travel may be available on application.

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