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Regenerative treatment of periodontal defects with Guided Tissue Regeneration (GTR) and plasma rich in growth factors (PRGF). Characterization of early healing stages through 2D/3D imaging, PROMs and gingival crevicular fluid markers

   Institute of Dentistry

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  Dr Elena Calciolari, Prof Nikolaos Donos  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

This investigation aims to describe the early healing events (up to 4 weeks) in terms of 3D/2D volumetric and thermal changes, expression of gingival crevicular fluid (GCF) markers, as well as PROMs associated with the regeneration of periodontal intrabony defects performed with guided tissue regeneration (GTR) or plasma rich in growth factors (PRGF), both combined with a simplified papilla preservation flap (SPPF).

While this study will assess several additional outcomes as part of a large randomized, single-blind, parallel-group controlled trial (like changes in PPD (primary outcome) and other clinical and radiographic parameters), this PhD thesis will specifically focus on the application of non-invasive 3D/2D imaging technologies to describe the different intra-oral/extra-oral healing patterns during periodontal regeneration, on the expression of specific GCF markers and on the characterization of PROMs. More specifically, for this PhD project we will consider the following outcomes:

Primary outcome: Post-operative swelling, oedema and change in temperature at different early healing time points (2, 7, 14, 30 days after surgical treatment) assessed with the help of 3D intra and extraoral geometrical and extra-oral 2D Thermal imaging

Secondary outcomes:  - Changes in patients’ reported outcomes (PROMs) measured with Global ratings of Periodontal Health and Quality of Life, global changes in quality of life, EuroQol-5D-5L and patient perception about therapy up to 1 month post-surgical treatment; - visual assessment of gingival healing and early healing index up to 2 weeks post-surgical treatment; - changes in GCF markers of inflammation, angiogenesis and bone formation at different early healing time points (2, 7, 14, 30 days after surgical treatment)

The study has already received funding from Osteology Foundation (PI: N. Donos) and has already received ethics approval. Registration in has also been obtained. Patient recruitment started (10 patients out of 74 originally planned have been recruited) and visits are ongoing.  

Funding Notes:

The Trustees of The Medical College of Saint Bartholomew’s Hospital Trust (MCSBHT) have offered funding for a research studentship, for a clinically qualified candidate to commence in October 2023, leading to a PhD degree from The QMUL Faculty of Medicine and Dentistry.

This studentship will fund a student with a clinical qualification and GMC / GDC registration at any career stage below consultant. The Studentship will cover the successful candidate’s current clinical salary and will include PhD fees (at home fee rate) with up to £6000 pa for consumables. Further consumables / funding for travel may be available on application. 

Notice on Equality, Diversity and Inclusion: 

Barts and The London School of Medicine and Dentistry aims to promote an organisational culture that is respectful and inclusive irrespective of age, disability, gender reassignment, ethnicity, marriage or civil partnership, pregnancy and maternity, race, sex and religion or belief. Moreover, it seeks to ensure that intersectionality is recognised, with explicit acknowledgement of the interconnected nature of social identities including race, class and sex, where these facets can create overlapping levels of discrimination or disadvantage.

Privacy Statement – sharing personal data with HARP

When you apply to the Trust for PhD support, or at any time afterwards, where you also apply to the Health Advances in Underrepresented Populations and Diseases PhD programme (“HARP”), the Trust will share your personal information with the Directors of HARP and with the other organisations involved in that programme, namely Queen Mary University of London, City University of London, Barts Charity, Barts Health NHS Trust and East London Foundation Trust. This may involve sharing your completed application forms, including equality monitoring information, as well as your name and contact details, your CV, details of your skills, education and experience, your proposed areas of study, and other information supporting your application. Your personal data will be shared for the purposes of evaluating your application and, if your application is successful, to administer your participation in the HARP doctoral training programme.


Sculean, A., Nikolidakis, D., Nikou, G., Ivanovic, A., Chapple, I. L. & Stavropoulos, A. (2015) Biomaterials for promoting periodontal regeneration in human intrabony defects: a systematic review. Periodontol 2000 68, 182-216. doi:10.1111/prd.12086
Marcazzan, S., Taschieri, S., Weinstein, R. L. & Del Fabbro, M. (2018) Efficacy of platelet concentrates in bone healing: A systematic review on animal studies - Part B: Large-size animal models. Platelets 29, 338-346
Rakmanee T, Calciolari E, Olsen I, Darbar U, Griffiths GS, Petrie A, Donos N. Expression of growth mediators in the gingival crevicular fluid of patients with aggressive periodontitis undergoing periodontal surgery. Clin Oral Investig. 2019 Aug;23(8):3307-3318. PMID: 30498980.
Koidou VP, Hagi-Pavli E, Cross S, Nibali L, Donos N. Molecular profiling of intrabony defects' gingival crevicular fluid. J Periodontal Res. 2022 Jan;57(1):152-161. doi: 10.1111/jre.12948. Epub 2021 Nov 17. PMID: 34788472.
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