Imperial College London Featured PhD Programmes
University of Kent Featured PhD Programmes
University of West London Featured PhD Programmes
National University of Ireland, Galway Featured PhD Programmes
University of Reading Featured PhD Programmes

Regulation of appetite during inflammation and its functional implication for disease outcomes (Manchester-Melbourne Dual Award)


Project Description

Inflammation requires energy to fight infection and sustain immune responses, yet during inflammation there is a dramatic loss of appetite. This loss of appetite (anorexia) is considered adaptive, however how inflammation impact on brain circuits controlling appetite and how anorexia impacts on disease progression and outcomes remain largely unknown.

The advent of new genetic technologies now provides a powerful means by which to unravel the contribution of discrete neurone populations to behaviour and physiology with unprecedented spatial and temporal resolution. Using these technologies, the host laboratories have identified brain hubs where inflammatory activity and appetite regulation intersect and have started to characterise the brain circuits involved.

The overarching aim of this project is to resolve these circuits and characterise them at the genetic, structural and functional level. To this end, the student will receive training in using the latest genetic technologies available that will allow him/her to genetically tag distinct neurones after they have responded to nutritional and/or inflammatory signals. When combined with preclinical models of inflammatory disease, these genetic technologies will then allow the student to identify the neurones and their connections, record their activity and selectively activate/inhibit them to interrogate their significance to normal physiology and inflammation.

These studies have important medical implications: they have the potential to improve our understanding of appetite regulation during inflammation and to identify novel strategies to ameliorate the effects of inflammatory diseases.

See https://www.manchester.ac.uk/study/postgraduate-research/golden/melbourne/

Funding Notes

This project is available to UK/EU candidates. Funding covers fees and stipend for 3.5 years. Candidates will be required to split their time between Manchester and Melbourne.

Applications should be submitted online and candidates should make direct contact with the Manchester supervisor to discuss their application directly. Applicants must have obtained, or be about to obtain, at least an upper second class honours degree (or equivalent) in a relevant subject.

As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

References

Aviello G, Singh AK, O'Neill S, Conroy E, Gallagher W, D'Agostino G, Walker AW, Bourke B, Scholz D, Knaus UG. Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects. Mucosal Immunol. 2019 Nov;12(6):1316-1326.

D'Agostino G, Lyons D, Cristiano C, Lettieri M, Olarte-Sanchez C, Burke LK, Greenwald-Yarnell M, Cansell C, Doslikova B, Georgescu T, Martinez de Morentin PB, Myers MG Jr, Rochford JJ, Heisler LK. Nucleus of the Solitary Tract Serotonin 5-HT(2C) Receptors Modulate Food Intake. Cell Metab. 2018 Oct 2;28(4):619-630.e5.

Dodd GT, Michael NJ, Lee-Young RS, Mangiafico SP, Pryor JT, Munder AC, Simonds SE, Brüning JC, Zhang ZY, Cowley MA, Andrikopoulos S, Horvath TL, Spanswick D, Tiganis T. Insulin regulates POMC neuronal plasticity to control glucose metabolism. Elife. 2018 Sep 19;7.

Dodd GT, Andrews ZB, Simonds SE, Michael NJ, DeVeer M, Brüning JC, Spanswick D, Cowley MA, Tiganis T. A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding. Cell Metab. 2017 Sep 5;26(3):577.

Marcinkiewcz CA, Mazzone CM, D'Agostino G, Halladay LR, Hardaway JA, DiBerto JF, Navarro M, Burnham N, Cristiano C, Dorrier CE, Tipton GJ, Ramakrishnan C, Kozicz T, Deisseroth K, Thiele TE, McElligott ZA, Holmes A, Heisler LK, Kash TL. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nature. 2016 Sep 1;537(7618):97-101.

Dodd GT, Decherf S, Loh K, Simonds SE, Wiede F, Balland E, Merry TL, Münzberg H, Zhang ZY, Kahn BB, Neel BG, Bence KK, Andrews ZB, Cowley MA, Tiganis T. Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell. 2015 Jan 15;160(1-2):88-104.

Dodd GT, Worth AA, Nunn N, Korpal AK, Bechtold DA, Allison MB, Myers MG Jr, Statnick MA, Luckman SM. The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab. 2014 Oct 7;20(4):639-49.

Dodd GT, Williams SR, Luckman SM. Functional magnetic resonance imaging and c-Fos mapping in rats following a glucoprivic dose of 2-deoxy-D-glucose. J Neurochem. 2010 Jun;113(5):1123-32.

D'Agostino G, La Rana G, Russo R, Sasso O, Iacono A, Esposito E, Mattace Raso G, Cuzzocrea S, Loverme J, Piomelli D, Meli R, Calignano A. Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia. Eur J Pharmacol. 2009 Jun 24;613(1-3):54-9.

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here
* required field
Send a copy to me for my own records.

Your enquiry has been emailed successfully





FindAPhD. Copyright 2005-2020
All rights reserved.