Applications are invited for a 4 year PhD studentship within the Sawarkar lab at the MRC Toxicology Unit, University of Cambridge.
Human cells are constantly exposed to environmental stress. We have evolved elaborate mechanisms to mount appropriate response to adapt to the stress. The transcriptional branch of the stress response has been intensely investigated focussing primarily on protein-coding genes. Our current work has identified that tRNA synthesis is highly regulated during stress. How stress affects RNA Polymerase III that transcribes tRNA remains unknown We have conducted genome-wide CRISPR-Cas9 screen and identified several trans-regulators of this process. The project will investigate how these trans-regulators communicate with stress-signalling pathway and how the pathway is modified in cancer and neurodegeneration with the hope of identifying therapeutics.
The Medical Research Council (MRC) Toxicology Unit is a leading International Research Institute within the School of Biological Sciences, University of Cambridge. The Unit delivers mechanistic toxicology research, pursuing hypothesis-driven toxicological questions with a particular focus on the study of the causal links between exposure to endogenous and exogenous toxicants, molecular initiating events and adverse outcome pathways. The Unit's overall aims are to carry out pioneering research which leads to improved health and to train and mentor the next generation of toxicologists.
The Unit provides a supportive learning environment designed to meet the scientific and transferable skills required for an internationally competitive career. Our PhD Programme aims to train the scientific leaders of the future, giving them rewarding research projects with access to world-class facilities and expertise.
Applicants should have or shortly expect to obtain a first or good upper second-class degree from a UK university, or an equivalent standard from an overseas university, in a relevant subject such as Biomedical Science. Strong analytical skills, in addition to creativity, curiosity, enthusiasm, and the ability to work in a team are essential.
You are strongly recommended to contact the project supervisor prior to submitting your formal application to find out more about the project and eligibility: Dr Ritwick Sawarkar [Email Address Removed]
Information regarding the application process can be found at: PhD Programme | MRC Toxicology Unit (cam.ac.uk)
All formal applications will need to be made through the University Application Portal:
PhD in Biological Science (MRC Toxicology Unit) | Postgraduate Admissions (cam.ac.uk)
Your online application must include:
• A CV, including full details of all University course grades to date -
• Contact details for two academic or professional referees
• A personal statement of interest
Closing date: Friday 31st March 2022 or until a suitable candidate is found. Early applications are recommended.