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Regulation of innate and adaptive immunity by EROS

  • Full or part time
  • Application Deadline
    Thursday, February 28, 2019
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Project Details:

We invite applications for a Department of Medicine-funded PhD studentship in the laboratory of Dr David Thomas to investigate the function of EROS (gene symbol CYBC1, previously C17ORF62.), a novel transmembrane protein that we have recently shown plays key roles in several aspects of immune system function both in mouse and human (Thomas et al (2017) Journal of Experimental Medicine 214 (4), 1111-1128) and (Thomas et al 2018 Journal of Allergy and Clinical Immunology, in press). Specifically, Eros is essential for the generation of reactive oxygen species and host defence against common infections but its exact mechanism of action and role in all cell types remain to be determined.

The aim of this PhD studentship is to investigate the specific roles of EROS in a variety of settings. The project is likely to examine (i) the role of EROS in cells of the adaptive immune system, including its role in autoimmunity (ii) the role of EROS in processes distinct from the generation of reactive oxygen species (iii) EROS’s subcellular localisation and interactome in order to gain insight into its mechanism of action.

The project will also involve collaborating with colleagues at other institutes including the Wellcome Trust Sanger Institute and the Laboratory of Molecular Biology (LMB). The post will involve the use of in vitro and in vivo models to study the function of Eros within immune cells to assess its function in a variety of cell types and species. The project will provide training in cell culture, proteomics, molecular and/or cellular immunology, cloning and in vivo models of disease. Additional training will be provided where necessary.

Requirements:

Applicants must have/or expect to gain a first class or upper second class honours degree or Overseas equivalent in a relevant subject area (biochemistry and immunology) preferably with experience with in vivo immunology assays and models. A Master’s Degree is preferable but not essential. We look for highly motivated applicants with excellent interpersonal, written and oral communication skills.

How to Apply:

Applicants are requested to send a full CV (including the names and email addresses of at least two academic referees), and personal statement (detailing why you are interested in the research project). Suitable candidates will be then asked to complete an electronic application form at Imperial College London in order for their qualifications to be addressed by College Registry.

Please submit your application to Rena John-Lewis (). Informal enquiries can be directed to David Thomas ().

Funding Notes

Stipend: £18,000 (inclusive of London allowance) per annum + Tuition Fees (Home/EU rate) for 3 years.

A tax-free stipend and home UK/EU fees for 3 years will be awarded. Overseas students should be able to demonstrate adequate financial support to cover the difference between the home/EU fee and the overseas fee. Applicants are also required to meet Imperial College’s English language requirements. Please see the following link: View Website

References

1. EROS mutations: decreased NADPH oxidase function and chronic granulomatous disease. David C. Thomas*, Louis-Marie Charbonnier*, Andrea Schejtman, Hasan Aldhekri, Eve L. Coomber, Elizabeth R. Dufficy, Anne E. Beenken, James C. Lee, Simon Clare, Anneliese O. Speak, Adrian J. Thrasher, Giorgia Santilli, Hamoud Al-Mousa, Fowzan S. Alkuraya, Talal A. Chatila, Kenneth G.C. Smith. Journal of Allergy and Clinical Immunology 2018 DOI: https://doi.org/10.1016/j.jaci.2018.09.019, published online October 9th 2018

2. Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity. David C. Thomas1*, Simon Clare2*, John Sowerby1, Mercedes Pardo2, Jatinder Juss3, David Goulding2, Louise Van der Weyden2, Daniel Storisteanu3, Ananth Prakash4, Marion Espeli1, Shaun Flint1, James Lee1, Leanne Kane2, David Adams2, Alex Bateman4, Jyoti Chaudhry2, Paul Lyons1, Alison Condliffe3, Edwin Chilvers3, Gordon Dougan2Ϯ and Ken Smith1Ϯ - Journal of Experimental Medicine 2017 DOI: 10.1084/jem.20161382 | Published March 28, 2017

3. How the phagocyte NADPH oxidase regulates innate immunity: Thomas DC. Free Radic Biol Med. 2018 Sep;125:44-52. doi: 10.1016/j.freeradbiomed.2018.06.011. Epub 2018 Jun 25. Review.

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