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Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree (or equivalent) in a related area / subject. Candidates with experience in biomedical sciences or with an interest in immunology are encouraged to apply.
This project has a Band 3 fee. Details of our different fee bands can be found on our website (https://www.bmh.manchester.ac.uk/study/research/fees/). For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/).
Informal enquiries may be made directly to the primary supervisor.
Fenton TM, Kelly A, Shuttleworth EE, Smedley C, Atakilit A, Powrie F, Campbell S, Nishimura SL, Sheppard D, Levison S, Worthington JJ, Lehtinen MJ, Travis MA (2017). Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8. Mucosal Immunology, 10:624-634.
Mann, E.R., Bernardo, D., English N.R., Landy, J., Al-Hassi, H.O., Peake, S.T.C., Man, R., Elliott, T., Spranger, H., Parian, A., Brant, S., Lazarev, M., Hart, A.L., Li, X. and Knight, S.C. (2016). Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum. Gut. 65(2):256-70
Mann, E.R., Bernardo, D., Al-Hassi, H.O., Landy, J., Peake, S.T.C., Man, R., Han Lee, G., Yassin, N., Sarkar, S., Elliott, T., Thomas, L.V., Knight, S.C. and Hart, A.L. (2015). Human gut dendritic cells in ulcerative colitis drive aberrant, gut- specific T-cell responses characterised by increased IL-4 production and a loss of IL-22 and IFNγ. Inflammatory Bowel Diseases. 20(12): 2299-2307.
Worthington JJ, Kelly A, Smedley C, Bauché D, Campbell S, Marie JC, Travis MA (2015). Integrin αvβ8-mediated TGFβ activation by effector regulatory T-cells is essential for suppression of T-cell-mediated inflammation. Immunity, 42, 903-915.
Mann, E.R. and Li, X. Intestinal antigen-presenting cells in mucosal immune homeostasis: crosstalk between dendritic cells, macrophages and B-cells (2014). World Journal of Gastroenterology. 7;20(29):9653-64.