Regulation of plant stem cells by nutrient signals

Unlike animals, plants generate organs throughout their life cycle. Postembryonic development relies on stem cell reservoirs localized in specialized tissues known as meristems which finely balance cell proliferation and differentiation to allow life-long growth. The shoot apical meristem is the site where above-ground organogenesis is initiated, giving rise to leaves, axillary buds, flowers, and the stem. Organ formation and growth is largely dictated by the environment through a poorly understood integration of internal and external signals. We have recently identified a protein kinase that is important for adjusting plant growth to the environment, regulating meristem activity in response to light and nutrient signals. However, the underlying mechanisms remain unclear.

The aim of this PhD project is to investigate the mechanisms by which this protein kinase modulates meristem activity. To this end, the student will focus on 3 strong candidate factors identified as interactors of this kinase in our lab. The student will use a combination of in vitro approaches, transient cell-based assays, transgenic plants and meristem imaging to investigate the functional relationship between these factors and the kinase and how that impacts meristem activity and organ formation. Interested candidates with a background in Biology or related fields (e.g. Biochemistry, Biotechnology) are encouraged to contact Dr. Baena-Gonzalez ([Email Address Removed]) with their CV, two letters of reference, and a brief statement of interest (maximum 500 words). Please add "Gatsby studentship" in the subject of the email.

One candidate will be selected to work on a project proposal. They will then compete at interview, with up to 7 other candidates, for one of up to four Sainsbury PhD Studentships. Interviews will be held in London on 13^th January, 2023. It is expected that the studentship holder spends six months during the 3^rd or 4^th year at another university/institute to gain additional experience. Please note that students are not normally allowed to apply to the institution where they carried out their undergraduate degree.