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Regulation of protein degradation and homeostasis by the ubiquitin system

About This PhD Project

Project Description

University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom

Dr. Yogesh Kulathu

Protein degradation is a fundamental process that is important for timely elimination of damaged proteins. This process relies on modification of proteins with ubiquitin, a signal to target destruction of modified proteins. Ubiquitylation is a very dynamic process and ubiquitin signals are removed/edited by deubiquitinating enzymes (DUBs). Failure to eliminate damaged/misfolded proteins is an underlying cause of age-related diseases such as Alzheimer’s and Parkinson’s disease. In the lab, we employ a range of techniques including biochemical approaches, state-of-the-art proteomics, structural biology and mouse models to elucidate new layers of control in protein degradation, research that will advance our understanding of neurodegenerative diseases.

We recently discovered a new family of DUBs that regulate protein degradation signals. The available projects build on our exciting, unpublished findings that these DUBs are novel regulators of protein homeostasis. In this PhD project, you will use innovative genetic and cell biology techniques to dissect how MINDY DUBs control protein degradation. Specifically, you will address how protein degradation is regulated in different subcellular compartments. This project has the potential to unravel novel pathways modulating protein homeostasis, and how these can be manipulated in neurodegenerative diseases.
For informal enquiries please email Yogesh Kulathu:

At the MRC PPU, as well as the possibility of a PhD in one particular lab, we offer the possibility of two 4.5-month rotations in labs of their choice. A range of other projects from MRC PPU scientists are advertised on this website. Rotations provide valuable experience and help with deciding on the choice of PhD project and research group.

Please send a CV with contact details of three referees to and a cover letter explaining why you have chosen to apply to MRC PPU to . The closing date for this round of applications is March 31st 2019 with interviews in April.

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