About the Project
Our extensive mass spectrometry analyses of the post-termination replication machinery and whole chromatin upon inhibition of replisome dissolution provides us with potential candidates for modifying enzymes or factors regulating its disassembly or replication fork termination.
This project aims at characterisation of the function and importance of these candidates in process of replication machinery disassembly. The studies will be performed to start with in cell free system of Xenopus laevis egg extract and the findings obtained will be then translated to human immortalised cell lines.
Techniques used: Recombinant protein production; Protein biochemistry: in vitro, in extracto and in vivo; Electron microscopy and single molecule microscopy; Cell biology – fluorescent microscopy, survival etc.
More details of the project can be found at:
This project is funded through MIBTP training programme. Funding provided is for student fees at UK/home level, studentship and bench fees.
For details of the training programme and how to apply please visit:
Please note that you need to apply through both Warwick website to access MIBTP application and Birmingham website to access University of Birmingham PhD application.
2. Moreno SP, Gambus A. Mechanisms of eukaryotic replisome disassembly. Biochem Soc Trans. 2020 Jun 30;48(3):823-836. doi: 10.1042/BST20190363
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