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Regulation of T cell immunity in human barrier tissues - PhD position in Munich


Project Description

The Technical University of Munich (TUM) is one of the most renowned Universities in Europe. The research group is located in a prestigious newly built research building, TranslaTUM, which is dedicated to interdisciplinary translational research. We are offering:

1 PhD Position

Successful candidates will employ state-of-the-art experimental approaches, cutting-edge analysis tools for immune regulatory mechanisms to pursue projects in molecular and cellular immunology. The research group headed by Prof. C. Zielinski focusses on human T cell immunology and questions related to the generation, maintenance and plasticity of human T helper cell subsets in health and disease (Zielinski et al. Nature 2012, Noster et al. Sci Transl Med 2015, Matthias J et al. Sci TranslaTUM Med 2019). The prospective candidates will have the opportunity to investigate the regulation of human tissue resident T cells. This is relevant to understand how barrier organs provide first-line defence against invading pathogens, how tissue-specific autoimmunity is regulated and how to exploit these mechanisms for immunotherapies.

The Technical University of Munich is committed to a family-oriented policy and an equal opportunity employer. We are looking to fill the positions as soon as possible.

Applications should be sent by email to Prof. Dr. Christina Zielinski, TranslaTUM, Technical University of Munich, Germany. Please provide a CV, letter of motivation and contact details of referees.
Email:

http://www.zielinskilab.com

Funding Notes

The position in fully funded

References

J. Matthias, J. Maul, R. Noster, H. Meinl, Y.-Y. Chao, H. Gerstenberg, F. Jeschke, G. Gilles, A. Welle, J. Walter, K. Nordstroem, K. Eberhardt, D. Renisch, S. Donakonda, P. Knolle, D. Soll, S. Grabbe, N. Garzorz-Stark, K. Eyerich, T. Biedermann, D. Baumjohann, C. E. Zielinski. (2019) Sodium chloride is an ionic checkpoint for human Th2 cell responses and shapes the atopic skin microenvironment. Sci Transl Med 2019 Feb 20;11(480)

Noster, R., Riedel, R., Mashreghi, M.F., Radbruch, H., Harms, L., Haftmann, C., Chang, H.D., Radbruch, A., and Zielinski, C.E. (2014). IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells. Sci Transl Med 6, 241ra280.

Zielinski, C.E., Mele, F., Aschenbrenner, D., Jarrossay, D., Ronchi, F., Gattorno, M., Monticelli, S., Lanzavecchia, A., and Sallusto, F. (2012a). Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Nature 484, 514-518.

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