About the Project
As part of an ongoing collaboration between Queens University Belfast and the University of Dundee, we have access to a large number of clinical samples and extensive clinical and biomarker data from patients enrolled in the European Bronchiectasis Registry (EMBARC). In this project, we will determine whether microbiota composition and presence of resistance genes in these samples correlates with antibiotic treatment. Metagenomic analysis will be performed to determine the abundance of genes encoding antimicrobial resistance, the ’resistome’, within the community of bacteria as a whole, and how it changes in response to treatment. The relationship between development of resistance and an extensive range of clinical outcomes (lung function, quality of life, time to next exacerbation) and measures of inflammation will also be determined.
Important, applicants must fulfil the eligibility criteria set out by the Department for the Economy which can be found at this link: View Website
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