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Reliability and Repeatability of Single Voxel Spectroscopy combined with MRI for Non-Invasive Measurements of Metabolites at 1.5T

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  • Full or part time
    Dr R Morris
    Prof C Sale
    Dr M Newton
  • Application Deadline
    Applications accepted all year round
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Single Voxel Spectroscopy is a powerful technique employed in magnetic resonance imaging systems allowing visualisation of a chemical shift spectrum for a chosen region of interest. There has been much debate over the optimum field strength for measurements and correlating measurements with measurements from biopsy is prone to difficulties arising from small sample size and whole muscle variations. In this project the student will first establish a standard protocol for use of the Siemens Avanto Single Voxel Spectroscopy (SVS) package for use in target muscles. The repeatability, reliability and similarity to muscle biopsy will then be determined in comparison to biopsied tissues including determination of the limit of detection for key metabolites. Motivated candidates will also have the opportunity to improve the existing sequences and processing modalities to provide improved spectral resolution verification which will include completion of the Siemens pulse sequence training course. It is expected that candidates will undertake preparation of ethical approval documentation in addition to normal duties which include preparing manuscripts for publication, reporting to supervisory team members, demonstrating in undergraduate and post-graduate laboratories, presenting work at conferences and working alongside other members of the groups.

Entry requirement
A first class or upper second class U.K. B.Sc. (Hons) degree (or equivalent) or Master degree with minimum of merit

Funding Notes

This is a self-funded position. Full-time PhD registration is for a minimum of 3-4 years.
Home/EU tuition fees: £4,121 (likely to rise in each subsequent year)
International tuition fees: £12,600 (likely to rise in each subsequent year)
Bench fee (annual): £8,000
If a student has not submitted his/her thesis by the end of year 3, he/she is required to enrol for a fourth year and pay the Completion Year Fee to enable him/her to complete and submit the thesis. The Completion Year Fee is £590 for 2016/17 (increases every year). No Bench fee is payable in year 4.

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