Prof Stefan Diez
No more applications being accepted
Funded PhD Project (Students Worldwide)
About the Project
Center for Molecular and Cellular Bioengineering
For the EU-funded MSC-ITN project on the topic “Cooperative effects in biomolecular transport systems based on coupled motors” the Center for Molecular Bioengineering (B CUBE), the Chair of BioNano-Tools offers a position as
Research Associate / Early Stage Research
starting 1st of September 2020 for 36 months. The period of employment is governed by the Fixed Term Research Contracts Act (Wissenschaftszeitvertragsgesetz - WissZeitVG).
The project is funded by the MARIE SKŁODOWSKA CURIE Innovative Training Network (ITN) Artificial Molecular Machines (ArtMoMa) within the Horizon 2020 Programme of the European Commission [https://cordis.europa.eu/project/rcn/224720]. ITN ArtMoMa, a consortium of 20 partners composed of high profile universities, research institutions and companies located in 8 European countries, will train 15 ESRs (doctoral students) in a highly innovative and interdisciplinary scientific network. Scientifically, ITN ArtMoMa will explore ways in which controlled mechanical movements of molecules can be orchestrated and used in nanoscale systems. It will extend scientific boundaries and explore entirely new directions of fundamental research towards technologically relevant implementations, for example in the fields of medical treatment, material design, and energy conversion.
Tasks: biochemical preparation of motors proteins; setup of in vitro motility assays (in stepping and gliding geometry); development of strategies to mechanically couple molecular motors; dynamic acquisition of motor-driven cargo movement by high-resolution fluorescence microscopy and optical tweezers; quantitative image processing, data analysis and modeling.
here you will find the complete job offer: https://tu-dresden.de/stellenausschreibung/7643
Funding Notes
Requirements: university degree (MSc degree or equivalent) in (bio)physics, (bio)chemistry or (bio)nanoengineering. Applicants should be ambitious, curious, creative, energetic and bright minds with a strong eagerness to take part in the research and training activities of this project and have excellent English skills. The position will be located in Dresden, Germany. Secondments to international partner groups are envisioned. The ESR will receive a salary according to MCSA regulation, including a living allowance, a mobility allowance and a family allowance (if eligible). Applications from women are particularly welcome. The same applies to people with disabilities.
References
The particular project (ESR n°9) carried out in the research group of Prof. Stefan Diez at B CUBE (http://www.tu-dresden.de/bcube/diez, please feel welcome to contact stefan.diez@tu-dresden.de for further information), will explore cooperative effects in biomolecular transport systems. In particular, it is envisoned to study in vitro the velocity and force output of microtubule-based transport systems where several motors collectively transport a cargo. It will be of interest to study the influence of the motor coupling (soft vs. rigid) and the influence of the microtubule surface (roadblocks and post-translational modifications).