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Resistant Hypertension – pathological insights from cardiac microvascular perfusion and mechanics.


Project Description

Hypertension commonly predisposes to many cardiovascular complications, including atrial fibrillation, heart failure and stroke. Importantly the heart is responsible for blood pressure yet suffers the consequences of uncontrolled hypertension.

Despite modern antihypertensive drugs therapies, many patients remain resistant to treatments and lifestyle interventions. We hypothesise that abnormalities in cardiac microvascular perfusion and mechanics may underlie the pathophysiology of resistant hypertension.

Cardiac microvascular perfusion and mechanics will be assessed by sophisticated echocardiography. These novel techniques will enable a comprehensive assessment of the interaction between myocardial perfusion and cardiac structure and function.

We will study patients with resistant hypertension, who will be compared to patients with controlled essential hypertension and normotensive controls. Following aggressive efforts at blood pressure management, the impact on cardiac microvascular perfusion and mechanics will also be studied.

This is a 3-year project from an exciting collaboration based at the new Liverpool Centre for Cardiovascular Science, between Liverpool John Moores University, the University of Liverpool and the Liverpool Heart and Chest Hospital. As such the supervisory team will consist of clinical experts in disease management and cardiac imaging from all of the institutes.

The successful candidate will be educated to Masters level in a relevant subject. International applicants should provide appropriate proof of English language testing (e.g. IELTS certificate, 6.5 overall, minimum of 5.5 in each component).

Funding Notes

UK, EU and International students can apply for this studentship. This is a self-funded opportunity with a requirement for the student or sponsor to cover the cost of full tuition and bench fees. Applicants should expect to commence study in January or September 2019.

References

For an informal discussion about this opportunity please email Dr David Oxborough ([email protected]) for more information.

Applicants should email a CV, covering letter detailing their suitability for the project and contact details of two referees to Dr David Oxborough ([email protected])

Applicants must be available for interview either face to face or via teleconference.

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