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Resolution Mediator Therapy to Prevent Adverse Pregnancy Outcomes (APOs) Induced by Periodontal Dysbiosis

Project Description

The Institute of Dentistry at Queen Mary University of London is offering research training at the PhD level for the following project within the Centre of Oral Immunobiology and Regenerative Medicine. The project will be carried out within the state-of-the-art facilities at Queen Mary University of London. The post is ideal for a dentally qualified individual with specialist interest in periodontology and willing to pursue an academic/research career and/or to further understand the link between periodontitis and systemic health.

Periodontitis is an inflammatory disease of the tooth-supporting tissues (gingivae, connective tissues and alveolar bone) and has been previously associated with adverse pregnancy outcomes (APOs). However, traditional periodontal treatment, targetting the oral microbiota, has not been successful in decreasing the occurrence of APOs. Since inflammation is responsible for most of the tissue destruction in periodontitis and is the underlying cause of APOs, there is a critical need to evaluate alternative periodontal therapies that directly address the uncontrolled inflammation caused by the microbial dysbiosis in periodontitis. Natural mediators of resolution (i.e. resolvins) are receptor agonists that reduce inflammatory exudates and are known to initiate resolution in both oral and systemic inflammation. This PhD project will aim to determine the mechanisms behind the link between periodontal dysbiosis and APOs; and to explore the inflammation-regulatory actions of resolution mediators in APOs using experimental models of periodontal disease.

Funding Notes

The Trustees of The Medical College of Saint Bartholomew’s Hospital Trust (MCSBHT) have offered funding for three research studentships (two in medicine and one in dentistry), for clinically qualified candidates within the Barts and The London School of Medicine and Dentistry to commence in October 2020, leading to a PhD degree.

Funded studentships will be open to potential students with a clinical qualification and GMC / GDC registration at any career stage below consultant. They will be funded for three years at current, MRC rates. Studentships will include PhD fees (at home/EU levels) and up to £6000 pa for consumables. Further consumables / funding for travel may be available on application.

How good is research at Queen Mary University of London in Clinical Medicine?

FTE Category A staff submitted: 144.11

Research output data provided by the Research Excellence Framework (REF)

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