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Retinal vessel size and shape associations with brain structure and function


Project Description

The size and shape of retinal vessels might be early markers of decline in cognitive function and dementia. We have used novel artificial intelligence enhanced automated software to generate a rich quantitative characterization of retinal vessels in UK Biobank participants who underwent retinal imaging.

This project will use data reduction techniques such as factor analysis to derive summary statistics that are then related to structural brain imaging measures that have also been measured in UK Biobank participants, using techniques such as linear mixed models. The aim is to understand early retinal vessel changes, leading to development of indices of retinal vasculature that can be used as screening tests for diseases such as dementia.

SKILLS WE EXPECT A STUDENT TO DEVELOP/ACQUIRE WHILST PURSUING THIS PROJECT
Statistical methodology as relevant to the analysis of large datasets, management of large datasets.

This project is suitable for applicants with a BSc and preferably MSc in Image Processing / Medical Statistics / Epidemiology.

HOW TO APPLY
Potential applicants are strongly encouraged to contact the supervisors to discuss project details.

The current studentship is part of the MRC London Intercollegiate Doctoral Training Partnership (MRC-LID) between The London School of Hygiene and Tropical Medicine (LSHTM) and St. George’s University of London (SGUL)

Subsequently applications can be made by following the instructions on the MRC-LID site at http://mrc-lid.lshtm.ac.uk/apply/.

Please click on the following link for more information about the MRC-LID programme: http://mrc-lid.lshtm.ac.uk/

For more information on funding please go to: http://mrc-lid.lshtm.ac.uk/faqs/

The deadline for applications is Wednesday 1 January 2020.

Funding Notes

To be eligible for a full studentship award applicants must
(a) hold, or expect to obtain before September 2020, a 1st or 2.1 Honours degree (as a minimum), and
(b) be a UK or EU citizen, and
(c) have maintained ordinary residence in the UK continuously for the 3 years preceding 1 September 2020.

To be generally eligible for a fees-only studentship award applicants must
(a) hold, or expect to obtain before September 2020, a 1st or 2.1 Honours degree (as a minimum), and
(b) be a UK or EU citizen.

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